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SIRT1 / Sirtuin 1
sirtuin 1
The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.
| Gene Name: | sirtuin 1 |
| Family/Subfamily: | ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase |
| Synonyms: | SIRT1, SIR2-like protein 1, SIR2alpha, SIR2L1, Sirtuin 1, Sir2-like 1, Sirtuin type 1, HSIR2, HSIRT1 |
| Target Sequences: | NM_012238 NP_036370.2 Q96EB6 |
Publications (8)
1
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. PloS one. 2008 3:e2020. (ICC, IHC)
[PubMed:18414679]
[PMC:PMC2289879]
2
Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. Mohan M, Kumar V, Lackner AA, Alvarez X. Journal of immunology (Baltimore, Md. : 1950). 2015 194:291-306. (IF; Rhesus monkey)
[Full Text Article]
[PubMed:25452565]
[PMC:PMC4272908]
Related Antibodies: LS-B8356.
3
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Förstermann U, Li H. British journal of pharmacology. 2017 174:3443-3453. (WB; Mouse)
[Full Text Article]
[PubMed:28055105]
[PMC:PMC5610154]
Related Antibodies: LS-B1564.
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Antibodies
(108)
Type
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(108)
Target
SIRT1 / Sirtuin 1
(108)
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(97)
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Publications
No
(104)
Yes
(4)
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (7B7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SIRT1 / Sirtuin 1 Goat anti-Human Polyclonal (aa577-590) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (aa207-256) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (aa207-256) Antibody
Human
WB
Unconjugated
100 µl/$397
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (1F3) Antibody
Mouse, Rat, Primate, Human
ELISA, Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (1F3) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$435
SIRT1 / Sirtuin 1 Chicken anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (30-110 aa) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (pSer47) Antibody
Mouse, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (aa41-90) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (1F3) Antibody
Human, Non-Human Primate
Flo, ICC, IF, IHC, WB
Unconjugated
100 µl/$541
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal Antibody
Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (pSer47) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P
Unconjugated
100 µl/$412
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
SIRT1 / Sirtuin 1 Rabbit anti-Mouse Polyclonal (aa236-490) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
SIRT1 / Sirtuin 1 Rabbit anti-Human Monoclonal (Preservative Free) (032) Antibody
Human
ELISA
Unconjugated, Preservative Free
100 µl/$412
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$371
SIRT1 / Sirtuin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (aa552-676) (OTI5B2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
SIRT1 / Sirtuin 1 Mouse anti-Human Monoclonal (aa552-676) (Carrier-free) (OTI5B2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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