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| Catalog Number | Size | Price |
|---|---|---|
| LS-B1564-100 | 100 µl (0.5 mg/ml) | $485 |
Polyclonal Rabbit anti‑Human SIRT1 / Sirtuin 1 Antibody (aa207‑256, IHC, WB) LS‑B1564
Polyclonal Rabbit anti‑Human SIRT1 / Sirtuin 1 Antibody (aa207‑256, IHC, WB) LS‑B1564
Note: This antibody replaces LS-C30198
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
Sirtuin 1 antibody LS-B1564 is an unconjugated rabbit polyclonal antibody to human Sirtuin 1 (SIRT1) (aa207-256). Validated for IHC and WB. Cited in 4 publications.
Target
Human SIRT1 / Sirtuin 1
Synonyms
SIRT1 | SIR2-like protein 1 | SIR2alpha | SIR2L1 | Sirtuin 1 | Sir2-like 1 | Sirtuin type 1 | HSIR2 | HSIRT1
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide located between aa207-256 of human SIRT1 (Q96EB6, NP_036370). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Rabbit, Horse, Pig, Guinea pig (100%); Turkey, Xenopus (92%); Chicken (85%); Zebrafish (84%).
Epitope
aa207-256
Specificity
human SIRT1
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Western blot (0.5 µg/ml)
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Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B1564 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1564 was determined to be 5 ug/ml.
Presentation
PBS, 0.09% sodium azide, 2% sucrose
Storage
Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SIRT1 / Sirtuin 1
LSBio Ratings
SIRT1 / Sirtuin 1 Antibody (aa207-256) for IHC, WB/Western LS-B1564 has an LSBio Rating of
Publications (4.3)
Learn more about The LSBio Ratings Algorithm
Publications (4)
Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model. Yurube T, Hirata H, Kakutani K, Maeno K, Takada T, Zhang Z, Takayama K, Matsushita T, Kuroda R, Kurosaka M, Nishida K. Arthritis research & therapy. 2014 16:R31.
Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Smit-McBride Z, Forward KI, Nguyen AT, Bordbari MH, Oltjen SL, Hjelmeland LM. Molecular vision. 20:1569-78.
Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Förstermann U, Li H. British journal of pharmacology. 2017 174:3443-3453. (WB; Mouse)
The Involvement of Sirtuin 1 Dysfunction in High-Fat Diet-Induced Vascular Dysfunction in Mice. Ning Xia, Gisela Reifenberg, Christian Schirra, Huige Li. Antioxidants (Basel, Switzerland). 2022 March;11:
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Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse, Rat
Applications:
Immunofluorescence, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Reactivity:
Human
Range:
78-5000 pg/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/15/2024
Date Requested: 11/15/2024
