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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PPARG / PPAR Gamma
peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma (PPAR gamma), a NR1 Thyroid Hormone-Like Receptor, is a transcription factor that regulates genes involved in lipid metabolism and adipocyte differentiation and has been shown to affect placental differentiation and cell proliferation and differentiation pathways in various diseases such as Type II diabetes and atherosclerosis. Recently, PPAR gamma has been suggested to affect inflammatory digestive diseases (Dubuquoy et al. 2002). PPAR gamma binds target DNA as a heterodimer (with retinoid X receptors) and has several coactivators, including steroid receptor coactivator-1 (SRC-1) and PPAR-binding protein (PBP). Two isoforms of PPAR gamma protein have been identified: PPAR gamma2 contains 30 additional amino acids at the N terminus compared to PPAR gamma1. PPAR gamma2 is expressed mainly in adipose tissue, whereas PPAR gamma1 is expressed widely. Mutations in PPAR gamma2 have been implicated in the development of obesity and Type II diabetes. PPAR gamma is the molecular target of thiazolidinediones (TZDs), drugs used widely for treatment of Type II diabetes, and is believed to mediate the apoptotic effects of this class of drugs in a variety of cell types, including B and T lymphocytes. Altered expression of PPAR gamma and cyclooxygenase-2 (COX-2) and the subsequent modulation in the tissue levels of PGE(2) and 15-d-PGJ(2) may influence the development of human breast cancer and its progression to metastasis.
| Gene Name: | peroxisome proliferator-activated receptor gamma |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | PPARG, NR1C3, PPAR gamma, PPAR gamma 2, PPARG1, PPARG2, PPARgamma, CIMT1, GLM1, PPAR-gamma |
| Target Sequences: | NM_015869 NP_056953.2 P37231 |
Publications (6)
1
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine)
[Full Text Article]
[PubMed:26537238]
[PMC:PMC4841859]
Related Antibodies: LS-B651.
2
Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep. Ruoss S, Kindt P, Oberholzer L, Rohner M, Jungck L, Abdel-Aziz S, Fitze D, Rosskopf AB, Klein K, von Rechenberg B, Gerber C, Wieser K, Flück M. Physiological reports. 2018 November;6:e13833. [Full Text Article]
[PubMed:30393967]
[PMC:PMC6215759]
Related Antibodies: LS-C178333.
3
PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, Guignabert C, Sollier J, Nickel NP, Kaschwich M, Cimprich KA, Rabinovitch M. Cell reports. 2019 January;26:1333-1343. [Full Text Article]
[PubMed:30699358]
[PMC:PMC6436616]
Related Antibodies: LS-C209422.
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(202)
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(4)
PPARG / PPAR Gamma Mouse anti-Human Monoclonal (8D1H8F4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody
Duck, Squirrel, Boar, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Mink, Macaque, Orangutan, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-16) Antibody
Human, Monkey
GS, ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$535
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (pSer273) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$567
PPARG / PPAR Gamma Mouse anti-Human Monoclonal (aa170-270) (3A4A9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
PPARG / PPAR Gamma Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
WB
Unconjugated
50 µl/$356; 100 µl/$461
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa82-101) Antibody
Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody
Human, Macaque
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
PPARG / PPAR Gamma Mouse anti-Human Monoclonal (8D1H8F4) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 ml/$419
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (pSer112) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
PPARG / PPAR Gamma Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
WB
Unconjugated
100 µl/$424
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa95-124) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (50-130 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$688
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa157-274) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
PPARG / PPAR Gamma Mouse anti-Human Monoclonal Antibody
Mouse, Human
IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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