Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Gene Name: | BUB3 mitotic checkpoint protein |
Synonyms: | BUB3, Budding uninhibited by benomyl, HBUB3, BUB3L, Mitotic checkpoint component |
Target Sequences: | NM_004725 NP_004716.1 O43684 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.