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ACAN / Aggrecan
aggrecan
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
| Gene Name: | aggrecan |
| Synonyms: | ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG |
| Target Sequences: | NM_013227 NP_037359.3 P16112 |
Publications (5)
1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88.
[PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat)
[PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat)
[PubMed:22394620]
[PMC:PMC3446417]
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(87)
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ACAN / Aggrecan
(87)
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Human
(47)
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(27)
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(31)
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(22)
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(7)
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(11)
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(81)
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(1)
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(9)
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(7)
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(4)
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(2)
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(78)
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(6)
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(3)
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(7)
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(3)
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(7)
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(80)
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(1)
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(1)
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(1)
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(1)
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(1)
aa384-392
(1)
Publications
No
(87)
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
ACAN / Aggrecan Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
50 µg/$460
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa350-400) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$386
ACAN / Aggrecan Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
ACAN / Aggrecan Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
ACAN / Aggrecan Mouse anti-Human Monoclonal (7D4) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2 mg/$545
ACAN / Aggrecan Rabbit anti-Human Monoclonal (Cleaved-Asp369) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa34-147) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
ACAN / Aggrecan Mouse anti-Human Monoclonal (aa20-675) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
500 µg/$1,083
ACAN / Aggrecan Mouse anti-Human Monoclonal (7E1) Antibody
Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
0.2 mg/$471
ACAN / Aggrecan Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
500 µg/$631
![ACAN / Aggrecan Antibody - Immunofluorescence of monoclonal antibody to ACAN on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/acan-aggrecan-antibody-clone-2a8-ls-c196626/143813_4829083.jpg)
ACAN / Aggrecan Mouse anti-Human Monoclonal (2A8) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
ACAN / Aggrecan Rabbit anti-Human Polyclonal (290-370 aa, N-terminal) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACAN / Aggrecan Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ACAN / Aggrecan Goat anti-Human Polyclonal (aa20-675) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$962
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa320-369) Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ACAN / Aggrecan Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ACAN / Aggrecan Rabbit anti-Human Polyclonal (aa200-250) Antibody
Human
IHC
Unconjugated
100 µl/$393
ACAN / Aggrecan Rabbit anti-Human Polyclonal (Cleaved) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$431
ACAN / Aggrecan Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
ACAN / Aggrecan Rabbit-New Zealand White anti-Human Polyclonal (aa1440-1490) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
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product results
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