Human ACAN / Aggrecan

Mouse

Human (tested or 100% immunogen sequence identity)

Rat, Chicken, Fish

IgG1 Monoclonal

7D4

Unconjugated

Protein G purified

Unmodified

Purified human articular cartilage aggrecan.

Recognizes human aggrecan, a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS). Studies using a panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. These studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues. Ârecognizes epitopes within the N-terminal G1-IGD-G2 region of aggrecan, that has been identified as a cluster 1 isoform.

• IHC
• IHC - Paraffin
• IHC - Frozen
• Western blot
• Immunoprecipitation
• ELISA

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P16112 NCBI: NM_013227 NP_037359.3