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Vimentin

Vimentin is a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

Gene Name:	Vimentin
Synonyms:	VIM, Vimentin, vimenin
Target Sequences:	NM_003380 NP_003371.2 P08670

Publications (11)

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Rankin EB, Tomaszewski JE, Haase VH. Cancer research. 2006 66:2576-83. [PubMed:16510575] [PMC:PMC3514875]

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. Genes & development. 2007 21:2788-803. [PubMed:17974918] [PMC:PMC2045132]

Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, Rustgi AK. Molecular and cellular biology. 2008 28:687-704. [PubMed:17998334] [PMC:PMC2223422]

Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Ponzo MG, Lesurf R, Petkiewicz S, O'Malley FP, Pinnaduwage D, Andrulis IL, Bull SB, Chughtai N, Zuo D, Souleimanova M, Germain D, Omeroglu A, Cardiff RD, Hallett M, Park M. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:12903-8. [PubMed:19617568] [PMC:PMC2722321]

Genomic analysis of reactive astrogliosis. Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:6391-410. (ICC, IHC; Mouse) [PubMed:22553043] [PMC:PMC3480225]

Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro. Muir AB, Lim DM, Benitez AJ, Modayur Chandramouleeswaran P, Lee AJ, Ruchelli ED, Spergel JM, Wang ML. Experimental cell research. 2013 319:850-9. (ICC, IHC; Human) [PubMed:23237990] [PMC:PMC3593809]

Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C92412.

Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri NO, Almutairi M, Parry L, Wakeman JA, McFarlane RJ. Molecular cancer. 2017 16:84. (ICC, IHC-P; Human) [Full Text Article] [PubMed:28446200] [PMC:PMC5406905] Related Antibodies: LS-B7191.

Ductal tree ablation by local delivery of ethanol prevents tumor formation in an aggressive mouse model of breast cancer. Elizabeth Kenyon, Jennifer J Westerhuis, Maximilian Volk, Jeremy Hix, Shatadru Chakravarty, Ethan Claucherty, Erin Zaluzec, Lisa Ramsey, Zach Madaj, Galen Hostetter, Bryn Eagleson, Erik Shapiro, Anna Moore, Lorenzo F Sempere. Breast cancer research : BCR. 2019 November;21:129. [Full Text Article] [PubMed:31779648] [PMC:PMC6883550] Related Antibodies: LS-B291.

Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation. Quan He, Fangfei Wang, Takashi Honda, Kenneth D Greis, Andrew N Redington. Scientific reports. 2020 Apr;10:6127. [Full Text Article] [PubMed:32273567] [PMC:PMC7145828]

Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis. Yamana D, Shimizu T, Fan Y, Miura T, Nanashima N, Yamada T, Hakamada K, Tsuchida S. Cancer science. 2011 Apr;102:735-41. [Full Text Article] [PubMed:21214675] Related Antibodies: LS-C40195.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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