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Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
Gene Name: | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
Family/Subfamily: | Transporter , Solute:sodium symporter |
Synonyms: | SLC5A1, D22S675, HSGLT1, Na(+)/glucose cotransporter 1, Na+/glucose cotransporter 1, SGLT1, NAGT, Sodium-glucose transporter 1, Sodium/glucose cotransporter 1 |
Target Sequences: | NM_000343 NP_000334.1 P13866 |
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