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May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2.
Gene Name: | synaptotagmin I |
Family/Subfamily: | Synaptotagmin , Not assigned-Other |
Synonyms: | SYT1, SYT, SVP65, Synaptotagmin, Synaptotagmin 1, SytI, Synaptotagmin I, Synaptotagmin-1 |
Target Sequences: | NM_005639 NP_005630.1 P21579 |
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