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PLAP / Alkaline Phosphatase
Placental Alkaline Phosphatase
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
| Gene Name: | Placental Alkaline Phosphatase |
| Synonyms: | ALPP, ALP, Alkaline phosphomonoesterase, Glycerophosphatase, PALP, PLAP, PLAP-1, Alp1, Germ-cell alkaline phosphatase, Nagao isozyme, Regan isozyme |
| Target Sequences: | NM_001632 NP_001623.3 P05187 |
Publications (4)
1
Fusion of Epstein-Barr virus with epithelial cells can be triggered by v5 in addition to v6 and v8, and integrin binding triggers a conformational change in glycoproteins gHgL. Chesnokova LS, Hutt-Fletcher LM. Journal of virology. 2011 85:13214-23. (Human)
[Full Text Article]
[PubMed:21957301]
[PMC:PMC3233123]
Related Antibodies: LS-C44264.
2
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells. Xue L, Li Y, Chen J. Molecular medicine reports. 2017 15:3011-3018. (Flo; Human)
[Full Text Article]
[PubMed:28339035]
[PMC:PMC5428749]
Related Antibodies: LS-C44264.
3
alpha v beta 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov;109:19792-7. [Full Text Article]
[PubMed:23150579]
[PMC:PMC3511702]
Related Antibodies: LS-C44264.
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PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (H17E2) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated
0.2 mg/$486
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (H7E8) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (SPM593) Antibody
Human
IHC-P
Unconjugated
50 µg/$460
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM593) Antibody
Human
IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$419
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (8B6) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$386
Cancer Pathology
Cancer
PLAP / Alkaline Phosphatase Rabbit anti-Human Recombinant Monoclonal (ALPP/2899R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$318
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated
200 µg/$757
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IHC
Biotin Conjugated
100 µl/$973
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, Flo, IHC-Fr
FITC Conjugated
100 µl/$973
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IHC
PE Conjugated
100 µl/$973
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
125 µl/$460
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa282-309) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa282-309) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa56-83) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Cancer Pathology
Cancer
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$460
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa411-460) (HRP) Antibody
Dog, Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa411-460) (Biotin) Antibody
Dog, Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PLAP / Alkaline Phosphatase Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
PLAP / Alkaline Phosphatase Sheep anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 ml/$680
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (ALPP/516) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated
20 µg/$371; 100 µg/$574
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (Azide-free, BSA-free) (ALPP/516) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated, Azide-free, BSA-free
100 µg/$574
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