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| Catalog Number | Size | Price |
|---|---|---|
| LS-B17008-50 | 50 µg (0.2 mg/ml) | $460 |
IHC‑plus™ Monoclonal Mouse anti‑Human PLAP / Alkaline Phosphatase Antibody (clone SPM593, IHC) LS‑B17008
IHC‑plus™ Monoclonal Mouse anti‑Human PLAP / Alkaline Phosphatase Antibody (clone SPM593, IHC) LS‑B17008
Note: This antibody replaces LS-C390148
Antibody:
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (SPM593) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal (SPM593) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Alkaline Phosphatase antibody LS-B17008 is an unconjugated mouse monoclonal antibody to human Alkaline Phosphatase (PLAP). Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Target
Human PLAP / Alkaline Phosphatase
Synonyms
ALPP | ALP | Alkaline phosphomonoesterase | Glycerophosphatase | PALP | PLAP | PLAP-1 | Alp1 | Germ-cell alkaline phosphatase | Nagao isozyme | Regan isozyme
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG2b,k
Monoclonal
Clone
SPM593
Conjugations
Unconjugated
Purification
Protein G affinity chromatography
Modifications
Unmodified.
Also available Azide-free, BSA-free.
Immunogen
Recombinant full-length human ALPP protein.
Specificity
Human PLAP / Alkaline Phosphatase
Applications
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. Optimal dilution of the PLAP antibody should be determined by the researcher. No special pretreatment is required for the immunohistochemical staining of formalin-fixed tissues.
Presentation
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About PLAP / Alkaline Phosphatase
Validation
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
IHC-plus™ PLAP / Alkaline Phosphatase Antibody (clone SPM593) for IHC LS-B17008 has an LSBio Rating of
Laboratory Validation Score (4)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human
Applications:
IHC, IHC - Frozen, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Frozen, Western blot, ELISA
Species:
Human
Applications:
IHC, Western blot, ELISA
Species:
Human
Applications:
Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/22/2024
Date Requested: 12/22/2024
