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PDI / P4HB
prolyl 4-hydroxylase, beta polypeptide
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
| Gene Name: | prolyl 4-hydroxylase, beta polypeptide |
| Synonyms: | P4HB, ERBA2L, DSI, GIT, p4HB, p4Hbeta, PDIA1, PHDB, PO4DB, PROHB, Protocollagen hydroxylase, Protein disulfide-isomerase, PO4HB, PDI |
| Target Sequences: | NM_000918 NP_000909.2 P07237 |
Publications (4)
1
Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. Zhu Y, Xu H, Chen H, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C. Molecular & cellular proteomics : MCP. 2014 13:2593-603. (WB; Human, Rat)
[Full Text Article]
[PubMed:24997997]
[PMC:PMC4188989]
2
Temporal gene expression profiling of the rat knee joint capsule during immobilization-induced joint contractures. Wong K, Sun F, Trudel G, Sebastiani P, Laneuville O. BMC musculoskeletal disorders. 2015 16:125. (ICC; Human, Rat)
[Full Text Article]
[PubMed:26006773]
[PMC:PMC4443538]
Related Antibodies: LS-B3137.
3
Localization of collagen modifying enzymes on fibroblastic reticular cells and follicular dendritic cells in non-neoplastic and neoplastic lymphoid tissues. Ohe R, Aung NY, Meng H, Kabasawa T, Suto A, Tamazawa N, Yang S, Kato T, Yamakawa M. Leukemia & lymphoma. 2015 57:1687-96. (IHC; Human)
[Full Text Article]
[PubMed:26700650]
[PMC:PMC4926777]
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PDI / P4HB Mouse anti-Rat Monoclonal (aa499-509) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$505
PDI / P4HB Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$565
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
PDI / P4HB Mouse anti-Rat Monoclonal Antibody
Mouse, Rat, Hamster, Pig, Human
Flo, Func, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$485
PDI / P4HB Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
PDI / P4HB Rabbit anti-Bovine Polyclonal Antibody
Xenopus, Rat, Hamster, Pig, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey
WB
Unconjugated
50 µg/$597
PDI / P4HB Mouse anti-Rat Monoclonal (PE) (1D3) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
Flo
PE Conjugated
200 µg/$777
PDI / P4HB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
PDI / P4HB Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$434; 100 µg/$611
PDI / P4HB Mouse anti-Rat Monoclonal (1D3) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
EM, ICC, IF, IHC, WB
Unconjugated
200 µg/$625
PDI / P4HB Rabbit anti-Human Polyclonal (aa436-464) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PDI / P4HB Rabbit anti-Human Monoclonal (Preservative Free) (16) Antibody
Human
ELISA, ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
PDI / P4HB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PDI / P4HB Mouse Monoclonal (6-9H6) Antibody
Rat
IHC, IHC-P
Unconjugated
100 µg/$783
PDI / P4HB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PDI / P4HB Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
PDI / P4HB Rabbit anti-Human Polyclonal (aa23-227) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
PDI / P4HB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
PDI / P4HB Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PDI / P4HB Rabbit anti-Human Polyclonal (aa101-150) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Horse, Orangutan, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PDI / P4HB Rabbit anti-Human Polyclonal (aa29-313) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PDI / P4HB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IP, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
PDI / P4HB Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
HEK 293 Cells
Myc-DDK (Flag)
55.2 kDa
20 µg/$1,107
E. coli
His-GST
60.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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