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MAP1LC3A / LC3A

microtubule-associated protein 1 light chain 3 alpha

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.

Gene Name:	microtubule-associated protein 1 light chain 3 alpha
Synonyms:	MAP1LC3A, ATG8E, LC3, LC3A, MAP1BLC3, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3
Target Sequences:	NM_032514 NP_115903.1 Q9H492

Publications (11)

Pathogenic lysosomal depletion in Parkinson's disease. Dehay B, Bov J, Rodrguez-Muela N, Perier C, Recasens A, Boya P, Vila M. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:12535-44. (WB; Mouse, Human) [PubMed:20844148]

Silica nanoconstruct cellular toleration threshold in vitro. Herd HL, Malugin A, Ghandehari H. Journal of controlled release : official journal of the Controlled Release Society. 2011 153:40-8. (WB; Mouse, Human) [PubMed:21342660] [PMC:PMC3197243]

Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, Lee FS. The Journal of biological chemistry. 2011 286:15797-805. [PubMed:21367862] [PMC:PMC3091189] Related Antibodies: LS-C165694.

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C165699.

Autophagy patterns and prognosis in uveal melanomas. Giatromanolaki AN, Charitoudis GS, Bechrakis NE, Kozobolis VP, Koukourakis MI, Foerster MH, Sivridis EL. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011 24:1036-45. [PubMed:21499230] Related Antibodies: LS-C159363.

Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Journal of virology. 2011 85:10561-71. [PubMed:21835792] [PMC:PMC3187495] Related Antibodies: LS-C158634.

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and -synuclein aggregation. Chang CF, Huang HJ, Lee HC, Hung KC, Wu RT, Lin AM. Journal of pineal research. 2012 52:312-21. (WB; Mouse) [PubMed:22212051]

Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C. Journal of molecular neuroscience : MN. 2012 47:256-66. (IHC; Human) [PubMed:22411133]

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Jeong JK, Moon MH, Bae BC, Lee YJ, Seol JW, Kang HS, Kim JS, Kang SJ, Park SY. Neuroscience research. 2012 73:99-105. (WB; Human) [PubMed:22465415]

Macroautophagy abnormality in essential tremor. Kuo SH, Tang G, Ma K, Babij R, Cortes E, Vonsattel JP, Faust PL, Sulzer D, Louis ED. PloS one. 2012 7:e53040. (WB; Human) [PubMed:23300858] [PMC:PMC3531444]

Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease. Lara Cantarero , Elena Juárez-Escoto , Azahara Civera-Tregón , María Rodríguez-Sanz, Mónica Roldán, Raúl Benítez , Janet Hoenicka , Francesc Palau. The Breast : official journal of the European Society of Mastology. 2021 Jan;29:3589-3605. [Full Text Article] [PubMed:33372681] [PMC:PMC7823109] Related Antibodies: LS-C165694.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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