IRF3

interferon regulatory factor 3

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

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Products

Antibodies (112)

Type

Primary (112)

Target

IRF3 (112)

Reactivity

Human (87)

Mouse (44)

Rat (20)

African green monkey (1)

Bat (3)

Bovine (5)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Monkey (2)

Pig (5)

Sheep (3)

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IHC (41)

IHC-P (17)

WB (103)

Flo (7)

ChrIP (1)

DB (1)

ELISA (34)

ICC (8)

IF (34)

IP (8)

Peptide-ELISA (10)

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Host

rabbit (90)

mouse (21)

goat (1)

Product Group

Antibodies to Coronavirus-Associated Targets (112)

Coronavirus Antibodies Proteins cDNAs (112)

IHCPlus (5)

Isotype

IgG (62)

IgG1 (9)

IgG1,k (2)

IgG2a (4)

IgG2a,k (1)

IgG2b (4)

Clonality

monoclonal mc (20)

polyclonal pc (92)

Clone

1522CT766.58.24 (1)

3C8 (1)

3F10 (2)

IRF35I218 (1)

OTI2G3 (2)

OTI2G6 (2)

OTI4A1 (2)

OTI4D4 (2)

OTI5D2 (2)

OTI8G9 (2)

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APC Conjugated (4)

Azide-free (1)

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Carrier-free (6)

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Cy7 Conjugated (2)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (4)

Unconjugated (79)

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Epitope

aa1-360 (8)

aa1-406 (8)

aa46-72 (7)

aa27-169 (6)

aa351-400 (5)

pSer385 (5)

aa108-166 (3)

pSer396 (3)

320-400 aa (2)

C-Terminus (2)

aa100-150 (2)

pSer386 (2)

330-410 aa (1)

340-420 aa (1)

Ala379 (1)

Pro173 (1)

Val391 (1)

aa206-427 (1)

aa275-325 (1)

aa352-401 (1)

aa362-411 (1)

aa375-419 (1)

aa409-427 (1)

aa78-108 (1)

p385 (1)

p386 (1)

p396 (1)

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Publications

No (112)

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IHC-plus™ IRF3 Antibody LS-B182

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IRF3 Antibody (phospho-Ser385) LS-C357142

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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IRF3 Antibody (phospho-Ser385) LS-C199138

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IRF3 Antibody (clone 1522CT766.58.24) LS-C392581

Antibody:

IRF3 Mouse anti-Human Monoclonal (1522CT766.58.24) Antibody

Reactivity:

Human, African green monkey

Applications:

Flo, IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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IRF3 Antibody (320-400 aa) LS-C381472

Antibody:

IRF3 Rabbit anti-Human Polyclonal (320-400 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IRF3 Antibody (clone OTI4D4) LS-C114575

Antibody:

IRF3 Mouse anti-Human Monoclonal (OTI4D4) Antibody

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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IRF3 Antibody (clone OTI4D4, Carrier-free) LS-C784298

Antibody:

IRF3 Mouse anti-Human Monoclonal (Carrier-free) (OTI4D4) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ IRF3 Antibody LS-B135

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ IRF3 Antibody (aa275-325) LS-B11648

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Mouse Polyclonal (aa275-325) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$485

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IRF3 Antibody (clone 3C8) LS-C197546

Antibody:

IRF3 Mouse anti-Human Monoclonal (3C8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$423

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IHC-plus™ IRF3 Antibody LS-B2529

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

IRF3 Antibody (aa108-166, clone 3F10) LS-C45030

Antibody:

IRF3 Mouse anti-Human Monoclonal (aa108-166) (3F10) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$505

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IRF3 Antibody (aa46-72) LS-C322272

Antibody:

IRF3 Rabbit anti-Mouse Polyclonal (aa46-72) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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IRF3 Antibody (clone IRF35I218) LS-C342311

Antibody:

IRF3 Mouse anti-Human Monoclonal (IRF35I218) Antibody

Reactivity:

Human

Applications:

DB, Flo, ICC, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$486

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IRF3 Antibody LS-C499144

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IRF3 Antibody (phospho-Ser396) LS-C199140

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer396) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IRF3 Antibody (clone OTI2G3) LS-C114617

Antibody:

IRF3 Mouse anti-Human Monoclonal (OTI2G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

IRF3 Antibody (C-Terminus) LS-C413182

Antibody:

IRF3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$341

Select

IRF3 Antibody LS-C666490

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

IRF3 Antibody (C-Terminus) LS-C368606

Antibody:

IRF3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

IRF3 Antibody (phospho-Ser385) LS-C801186

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

IRF3 Antibody (aa351-400) LS-C30509

Antibody:

IRF3 Rabbit anti-Human Polyclonal (aa351-400) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

IRF3 Antibody (p385) LS-C821850

Antibody:

IRF3 Rabbit anti-Human Polyclonal (p385) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

IRF3 Antibody (phospho-Ser385) LS-C821851

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

IRF3 Antibody LS-C801642

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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