EP300 / p300

E1A binding protein p300

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity.

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Antibodies (95)

Proteins (7)

ELISA Kits (6)

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Target

EP300 / p300 (108)

Reactivity

Human (82)

Mouse (41)

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Chicken (1)

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rabbit (78)

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Wheat Germ Extract (1)

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IHC-plus™ EP300 / p300 Antibody (clone 1D2) LS-B6081

(5.0) Rating

(1) Publication(s)

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal (1D2) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$555

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PathPlus™ EP300 / p300 Antibody (aa1572-2371, clone RW128) LS-B215

Cancer

(5.0) Rating

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (RW128) Antibody

Reactivity:

Mouse, Rat, Mustelid, Primate, Human

Applications:

IF, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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EP300 / p300 Antibody (Internal) LS-C368791

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

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Human EP300 / p300 (Sandwich ELISA) ELISA Kit - LS-F6932

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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EP300 / p300 Antibody (phospho-Ser1834) LS-C353727

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (pSer1834) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$315

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EP300 / p300 Antibody (aa1351-1601) LS-C372927

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (aa1351-1601) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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EP300 / p300 Antibody (aa950-1000) LS-C287259

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (aa950-1000) Antibody

Reactivity:

Human

Applications:

ChIP-Seq, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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IHC-plus™ EP300 / p300 Antibody (aa1572-2371, clone RW109) LS-B8325

(4.0) Rating

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (RW109) Antibody

Reactivity:

Mouse, Rat, Mustelid, Primate, Human

Applications:

IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.2 ml/$460

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EP300 / p300 Antibody LS-C748082

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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EP300 / p300 Antibody (N-Terminus) LS-C352168

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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EP300 / p300 Antibody (phospho-Ser1834) LS-C342171

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (pSer1834) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$431

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EP300 / p300 Antibody (N-Terminus) LS-C413062

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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IHC-plus™ EP300 / p300 Antibody (clone 1B1) LS-B6080

(4.0) Rating

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal (1B1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

EP300 / p300 Antibody LS-C38015

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$751

Select

PathPlus™ EP300 / p300 Antibody (aa1-50) LS-B7613

Cancer

(5.0) Rating

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$440

Select

Mouse EP300 / p300 (Sandwich ELISA) ELISA Kit - LS-F8696

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

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Human EP300 / p300 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75666

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

264 kDa

Price:

20 µg/$215

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EP300 / p300 Antibody (N-Terminus, clone AC240) LS-C18791

Antibody:

EP300 / p300 Mouse anti-Human Monoclonal (N-Terminus) (AC240) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$574

Select

EP300 / p300 Antibody LS-C677822

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

EP300 / p300 Antibody (HRP) LS-C677826

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

EP300 / p300 Antibody LS-C813472

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

Mouse/Human/Rat EP300 / p300 (Cell-Based ELISA) ELISA Kit - LS-F2204

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

Select

Rat EP300 / p300 (Sandwich ELISA) ELISA Kit - LS-F8697

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$783

Select

EP300 / p300 Antibody (aa2065-2414) LS-C344035

Antibody:

EP300 / p300 Rabbit anti-Human Polyclonal (aa2065-2414) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Human EP300 / p300 Protein (Recombinant His, N-Terminal) (aa1351-1601) - LS-G24698

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.2 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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