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CFH / Complement Factor H

complement factor H

CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: complement factor H
Synonyms: CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement)
Target Sequences: NM_000186 NP_000177.2 P08603

Publications (6)

1
VEGF regulates local inhibitory complement proteins in the eye and kidney. The Journal of clinical investigation. 2017 January;127:199-214. [Full Text Article] [PubMed:27918307] [PMC:PMC5199702]
2
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Guo Lu, Weihong Liu, Xinying Huang, Yanxin Zhao. Arquivos de neuro-psiquiatria. 2020 February;78:76-80. [Full Text Article] [PubMed:32022122]
3
Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site. Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202:1210-1218. [Full Text Article] [PubMed:30642982]
4
Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS. Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Rossella Piras, Caterina Mele, Matteo Breno, Alessandra Cremaschi, Elena Bresin, Roberta Donadelli, Silvia Alizzi, Antonio Amoroso, Ariela Benigni, Giuseppe Remuzzi , Marina Noris. Frontiers in immunology. 2019 May;10:853. [Full Text Article] [PubMed:31118930] [PMC:PMC6504697] Related Antibodies: LS-C58560.
5
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins10<sup> Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany. Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius , Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi , Erik J M Toonen, Diana Pauly , SciFiMed consortium. Frontiers in immunology. 2021 Mar;12:660194. [Full Text Article] [PubMed:33868311] [PMC:PMC8044877]
6
CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J H Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris. Frontiers in genetics. 2021 Jun;12:670727. [Full Text Article] [PubMed:34211499] [PMC:PMC8240960] Related Antibodies: LS-C58560.
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Antibodies (127)
Primary (127)
CFH / Complement Factor H (127)
Human (74)
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No (126)
Yes (1)
CFH / Complement Factor H Antibody - Anti-Factor H antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-24) Antibody
Human
ELISA, Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
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CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-23) Antibody
Human
ELISA, IP, RIA, WB
Unconjugated
0.2 mg/$471
CFH / Complement Factor H Antibody - Anti-Factor H antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CFH / Complement Factor H Mouse anti-Human Monoclonal (OX-24) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CFH / Complement Factor H Antibody - Anti-Factor H antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CFH / Complement Factor H Goat anti-Human Polyclonal (aa577-588) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
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CFH / Complement Factor H Mouse anti-Human Monoclonal (Biotin) (OX-24) Antibody
Human
ELISA, Flo, IP, WB
Biotin Conjugated
100 µg/$352
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CFH / Complement Factor H Mouse anti-Human Monoclonal (FITC) (OX-24) Antibody
Human
Flo
FITC Conjugated
100 µg/$361
CFH / Complement Factor H Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CFH / Complement Factor H Goat anti-Human Polyclonal Antibody
Human
ELISA, ID, IHC, IHC-P, WB
Unconjugated
0.5 ml/$460
CFH / Complement Factor H Antibody - Western Blot; Sample: Recombinant CFH, Rat.
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CFH / Complement Factor H Rabbit anti-Rat Polyclonal (aa975-1217) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CFH / Complement Factor H Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CFH / Complement Factor H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CFH / Complement Factor H Mouse anti-Mouse Monoclonal (1A2) Antibody
Mouse, Rat
IHC, IHC-Fr, WB
Unconjugated
100 µg/$554
CFH / Complement Factor H Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using antibody at 1:100 dilution.
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CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa20-270) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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CFH / Complement Factor H Mouse anti-Human Monoclonal (10-10) Antibody
Human
ELISA, Flo, IHC-Fr, WB
Unconjugated
0.1 mg/$536
CFH / Complement Factor H Antibody - Immunochemical staining of mouse CFH in mouse liver with rabbit monoclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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CFH / Complement Factor H Rabbit anti-Mouse Monoclonal (Preservative Free) (012) Antibody
Mouse
IHC-P
Unconjugated, Preservative Free
100 µl/$412
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CFH / Complement Factor H Mouse anti-Human Monoclonal (10-10) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$832
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CFH / Complement Factor H Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated
100 µl/$1,054
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CFH / Complement Factor H Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$896
CFH / Complement Factor H Antibody - IHC of paraffin-embedded U373 xenograft using Factor H antibody at 1:200 dilution.
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CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa527-618) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
CFH / Complement Factor H Antibody - Western blot of recombinant CFH / Complement Factor H.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa860-1231) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
CFH / Complement Factor H Antibody - Western blot of recombinant CFH / Complement Factor H.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CFH / Complement Factor H Rabbit anti-Mouse Polyclonal (aa915-1156) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CFH / Complement Factor H Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CFH (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CFH.
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CFH / Complement Factor H Mouse anti-Human Monoclonal (aa125-346) (OTI5H5) Antibody
Human
WB
Unconjugated
100 µl/$434
CFH / Complement Factor H Antibody - CFH antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa751-780) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa751-780) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
Select
CFH / Complement Factor H Rabbit anti-Human Polyclonal (aa751-780) (Azide-free) (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CFH / Complement Factor H Sheep anti-Human Polyclonal Antibody
Human
ID
Unconjugated
1 ml/$351
CFH / Complement Factor H Antibody
Select
CFH / Complement Factor H Mouse anti-Rat Monoclonal Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).