Human CFH / Complement Factor H

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

10-10

Unconjugated

Protein A purified

Unmodified

Purified human factor H from serum.

Recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kD, and the less common form of 43 kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.

• IHC - Frozen
• Western blot
• Flow Cytometry
• ELISA

BBS, 0.1% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P08603 NCBI: NM_000186 NP_000177.2