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CD274 / B7-H1 / PD-L1
CD274 molecule
CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. It inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. Expression of CD274 in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma.
| Gene Name: | CD274 molecule |
| Synonyms: | CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1 |
| Target Sequences: | NM_014143 NP_054862.1 Q9NZQ7 |
Publications (19)
1
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 19:1225-31. (WB; Human)
[Full Text Article]
[PubMed:23307859]
[PMC:PMC3752683]
2
Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines. Yamane H, Isozaki H, Takeyama M, Ochi N, Kudo K, Honda Y, Yamagishi T, Kubo T, Kiura K, Takigawa N. American journal of cancer research. 2015 5:1553-7. (Flo; Human)
[PubMed:26101718]
[PMC:PMC4473331]
3
Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells. Karakhanova S, Link J, Heinrich M, Shevchenko I, Yang Y, Hassenpflug M, Bunge H, von Ahn K, Brecht R, Mathes A, Maier C, Umansky V, Werner J, Bazhin AV. Oncoimmunology. 2015 4:e998519. (Flo; Mouse)
[Full Text Article]
[PubMed:26137414]
[PMC:PMC4485765]
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CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (OTI2C7) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (PE) (27A2) Antibody
Human
Flo
PE Conjugated
1 ml/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal (aa261-290) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
CD274 / B7-H1 / PD-L1 Rat anti-Mouse Monoclonal (MIH5) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$305
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (27A2) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (ANC6H1) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$446
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (Biotin) (ANC6H1) Antibody
Human
ELISA, Flo
Biotin Conjugated
100 µg/$536
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (Azide-free) (ANC6H1) Antibody
Human
ELISA, Flo
Unconjugated, Azide-free
100 µg/$446
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Recombinant Monoclonal (RBT-PDL1) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$482; 0.5 ml/$1,041; 1 ml/$1,472
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
CD274 / B7-H1 / PD-L1 Rabbit anti-Mouse Polyclonal (aa34-241) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal (MIH3) Antibody
Flo
Unconjugated
100 µg/$430
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
CD274 / B7-H1 / PD-L1 Rabbit anti-Rat Polyclonal (aa34-241) (PE) Antibody
Rat
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IF, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Human
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Cancer Pathology
Cancer
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Monoclonal (AHC0271) Antibody
Human
IHC-P
Unconjugated
0.05 ml/$440
CD274 / B7-H1 / PD-L1 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC-P, WB
Unconjugated
100 µg/$351
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