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ALOX5 / 5-LOX
arachidonate 5-lipoxygenase
ALOX5 / 5-LOX is a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | arachidonate 5-lipoxygenase |
| Family/Subfamily: | Lipoxygenase , Not assigned-Other |
| Synonyms: | ALOX5, 5-lipoxygenase, 5LPG, 5-LO, 5-LOX, Arachidonate 5-lipoxygenase, LOG5, LOX-5, Leukotriene A4 synthase |
| Target Sequences: | NM_000698 NP_000689.1 P09917 |
Publications (1)
1
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Sudipta Das, Marina Miller, Andrew K Beppu, James Mueller, Matthew D McGeough, Christine Vuong, Maya R Karta, Peter Rosenthal, Fazila Chouiali, Taylor A Doherty, Richard C Kurten, Qutayba Hamid, Hal M Hoffman, David H Broide. Proceedings of the National Academy of Sciences of the United States of America. 2016 November;113:13132-13137. [Full Text Article]
[PubMed:27799535]
[PMC:PMC5135378]
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ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa130-149) Antibody
Bovine, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa600-674) Antibody
Rabbit, Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$750
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (pSer271) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa246-295) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His, N-Terminal
25.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa120-483) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (OTI1C1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (Carrier-free) (OTI1C1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (OTI2C5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (Carrier-free) (OTI2C5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (OTI3F1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (Carrier-free) (OTI3F1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (OTI1A1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ALOX5 / 5-LOX Mouse anti-Human Monoclonal (aa18-364) (Carrier-free) (OTI1A1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$341
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (220-300 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ALOX5 / 5-LOX Rabbit anti-Human Polyclonal (aa650-667) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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