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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16156-100 | 100 µl (1 mg/ml) | $460 |
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PathPlus™ Monoclonal Mouse anti‑Human NPM1 / NPM / Nucleophosmin Antibody (IHC, WB) LS‑B16156
PathPlus™ Monoclonal Mouse anti‑Human NPM1 / NPM / Nucleophosmin Antibody (IHC, WB) LS‑B16156
Note: This antibody replaces LS-C744546
Antibody:
NPM1 / NPM / Nucleophosmin Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
NPM1 / NPM / Nucleophosmin Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Nucleophosmin (NPM1) is a nuclear phosphoprotein that shuttles between the nucleolus and cytoplasm, and is involved in proliferation and growth-suppression pathways. It is involved in ribosome biogenesis, regulates centrosome duplication, and is involved in regulation of the ARF/p53 pathway. Overexpression correlates with cell transformation, and disruption can cause genomic instability and centrosome amplification. When mutated, NPM1 is trapped in the cytoplasm, and the aberrant cytoplasmic location has been used to identify NPM1 mutation status in AML patients. Translocations and fusions with several genes (ALK, RARalpha, MLF1) have been identified in various lymphomas and leukemias.
References: Nat Reviews Cancer 2006 6:493; Ind J Med Res 2016 143(6):763; Heamatologica 2013 98(10):1532; Haematologica 2007 92(4):519
Target
Human NPM1 / NPM / Nucleophosmin
Synonyms
NPM1 | NPM | Nucleolar phosphoprotein B23 | Nucleolar protein NO38 | Numatrin | B23 | Nucleophosmin
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Synthetic Nucleophosmin
Applications
- IHC (1:200 - 1:400)
- IHC - Paraffin (1:50)
- Western blot (1:200 - 1:400)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Use Heat-induced epitope retrieval (HIER) Citrate buffer of pH 6.0 Recommended IHC controls tissues are Tonsil, Colon. Resulting localization is Nuclear, Cytoplasmic
Presentation
0.5% BSA, 0.1% Kathon, Tris-Buffered Saline, DI H2O and 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NPM1 / NPM / Nucleophosmin
Validation
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ NPM1 / NPM / Nucleophosmin Antibody for IHC, WB/Western LS-B16156 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC - Paraffin, ICC, Western blot
Species:
Human
Applications:
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
![NPM1 / NPM / Nucleophosmin Antibody - Immunofluorescence of monoclonal antibody to NPM1 on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com//image2/npm1-npm-nucleophosmin-antibody-clone-3b2-ls-c133351/51336_1027566.jpg)
Species:
Human
Applications:
Immunofluorescence, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
