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PathPlus™ Polyclonal Rabbit anti‑Human CANX / Calnexin Antibody (C‑Terminus, IHC, IF, WB) LS‑B16505
PathPlus™ Polyclonal Rabbit anti‑Human CANX / Calnexin Antibody (C‑Terminus, IHC, IF, WB) LS‑B16505
Note: This antibody replaces LS-C351906
Antibody:
CANX / Calnexin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P, ICC, IF, WB, IP
Reactivity:
Human, Mouse, Rat, Bovine, Dog
Format:
Unconjugated, Unmodified
Overview
Antibody:
CANX / Calnexin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P, ICC, IF, WB, IP
Reactivity:
Human, Mouse, Rat, Bovine, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
CANX (also called calnexin) is a calcium-binding molecular chaperone protein that is involved in facilitating the assembly and folding of newly synthesized N-linked glycoproteins. It is a stress-induced protein located in the endoplasmic reticulum membrane. It is also found in melanosomes, where it appears to be involved in melanosome biogenesis. CANX is broadly expressed in normal and diseased tissues, and expression may be increased or decreased in certain types of cancers.
References: EMBO J. 2012;31(7):1823-1835. doi: 10.1038/emboj.2012.15; J Proteome Res. 2003;2(1):69-79. PMID: 12643545; J Transl Med. 2016;14(1):196. doi: 10.1186/s12967-016-0948-z; Cancer Lett. 2004;203(2):225-231. PMID: 14732231; Lung Cancer. 2015;90(2):342-345. doi: 10.1016/j.lungcan.2015.08.015; J Cell Mol Med. 2017;21(12):3141-3149. doi: 10.1111/jcmm.13413.
Target
Human CANX / Calnexin
Synonyms
CANX | CNX | Calnexin | IP90 | p90
Reactivity
Human, Mouse, Rat, Bovine, Dog
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-Terminus of human Calnexin.
Specificity
Recognizes endogenous levels of Calnexin protein.
Applications
- IHC - Paraffin (1:100)
- ICC (1:100 - 1:500)
- Immunofluorescence
- Western blot (1:500 - 1:1000)
- Immunoprecipitation (1:10 - 1:100)
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Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.3, 0.01% Sodium Azide, 30% Glycerol
Storage
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
Validation
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
LSBio Ratings
Laboratory Validation Score (5)
Featured Products
Species:
Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
Applications:
IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Species:
Human, Monkey, Mouse, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Monkey, Mouse, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024