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| Catalog Number | Size | Price |
|---|---|---|
| LS-B12410-200 | 200 µg (2 mg/ml) | $460 |
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PathPlus™ Polyclonal Goat anti‑Human CANX / Calnexin Antibody (C‑Terminus, IHC, IF, WB) LS‑B12410
PathPlus™ Polyclonal Goat anti‑Human CANX / Calnexin Antibody (C‑Terminus, IHC, IF, WB) LS‑B12410
Note: This antibody replaces LS-C204213
Antibody:
CANX / Calnexin Goat anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human, Monkey, Mouse, Rat, Dog
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CANX / Calnexin Goat anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human, Monkey, Mouse, Rat, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
CANX (also called calnexin) is a calcium-binding molecular chaperone protein that is involved in facilitating the assembly and folding of newly synthesized N-linked glycoproteins. It is a stress-induced protein located in the endoplasmic reticulum membrane. It is also found in melanosomes, where it appears to be involved in melanosome biogenesis. CANX is broadly expressed in normal and diseased tissues, and expression may be increased or decreased in certain types of cancers.
References: EMBO J. 2012;31(7):1823-1835. doi: 10.1038/emboj.2012.15; J Proteome Res. 2003;2(1):69-79. PMID: 12643545; J Transl Med. 2016;14(1):196. doi: 10.1186/s12967-016-0948-z; Cancer Lett. 2004;203(2):225-231. PMID: 14732231; Lung Cancer. 2015;90(2):342-345. doi: 10.1016/j.lungcan.2015.08.015; J Cell Mol Med. 2017;21(12):3141-3149. doi: 10.1111/jcmm.13413.
Target
Human CANX / Calnexin
Synonyms
CANX | CNX | Calnexin | IP90 | p90
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Dog
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Purified recombinant peptide within residues 550 aa to the C-Terminus of human CANX produced in E. coli.
Epitope
C-Terminus
Specificity
Detects a band of 90 kDa by Western blot in the following human (293A, primary fibroblasts, HaCat, HeLa, HMEC-1, Jurkat, MNT1, U-118), rat (TR-iBRB), mouse (3T3, AtT-20, Hepa, Raw264.7), monkey (COS-7) and canine (D17) whole cell lysates.
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Immunofluorescence (1:50 - 1:500)
- Western blot (1:500 - 1:2000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.05% Sodium Azide, 20% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CANX / Calnexin
Validation
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CANX / Calnexin Antibody (C-Terminus) for IHC, IF/Immunofluorescence, WB/Western LS-B12410 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy. Marieke C Verweij , Scott G Hansen , Ravi Iyer , Nessy John , Daniel Malouli, David Morrow, Isabel Scholz, Jennie Womack, Shaheed Abdulhaqq, Roxanne M Gilbride, Colette M Hughes, Abigail B Ventura, Julia C Ford, Andrea N Selseth, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J Bosche, Michael Hull, Jason Shao, Jonah B Sacha, Michael K Axthelm, Paul T Edlefsen, Jeffrey D Lifson, Louis J Picker, Klaus Früh. Science (New York, N.Y.). 2021 April;372:eabe9233.
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Monkey, Mouse, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Species:
Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
Applications:
IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/12/2024
Date Requested: 11/12/2024
