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TOP2A / Topoisomerase II Alpha
topoisomerase (DNA) II alpha 170kDa
TOP2A / Topoisomerase II Alpha is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
| Gene Name: | topoisomerase (DNA) II alpha 170kDa |
| Family/Subfamily: | Topoisomerase |
| Synonyms: | TOP2A, DNA topoisomerase II, 170 kD, TOP2, DNA gyrase, DNA topoisomerase 2-alpha, TP2A, Topoisomerase IIa |
| Target Sequences: | NM_001067 NP_001058.2 P11388 |
Publications (2)
1
Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Adler M, Mller K, Rached E, Dekant W, Mally A. Carcinogenesis. 2009 30:711-9. (IHC)
[PubMed:19237604]
2
3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha. Sofia Sagredou, Panagiotis Dalezis, Nikolaos Nikoleousakos, Michail Nikolaou, Maria Voura, Konstantinos Almpanakis, Mihalis I Panayiotidis, Vasiliki Sarli, Dimitrios T Trafalis. OncoTargets and therapy. 2020 August;13:7369-7386. [Full Text Article]
[PubMed:32801761]
[PMC:PMC7395825]
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TOP2A / Topoisomerase II Alpha
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Human
(2)
Source
293T Cells
(1)
HEK 293 Cells
(1)
Wheat Germ Extract
(1)
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$832
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (1050-1130 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (aa1100-1531) (1D2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (aa1100-1531) (UMAB145) Antibody
Human
IF, IHC, WB
Unconjugated
100 µl/$493
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (aa1100-1531) (Carrier-free) (UMAB145) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (aa1100-1531) (OTI5E6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (aa1482-1531) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (pSer1106) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Cancer Pathology
Cancer
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (1C5) Antibody
Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$423
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (1E2) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$423
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (TPM2A-2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TPM2A-2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (TPM2A-1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TPM2A-1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (TOP2A/1361) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
TOP2A / Topoisomerase II Alpha Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TOP2A/1361) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (aa1167-1196) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal (aa1167-1196) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
TOP2A / Topoisomerase II Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
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