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Infectious Disease
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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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Customer Service: (800) 227-6666 / (650) 697-3600
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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TNFRSF14 / CD270 / HVEM
tumor necrosis factor receptor superfamily, member 14
HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM. Soluble HVEM, which tends to form disulfide-linked heterodimeric complexes in solution, can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
| Gene Name: | tumor necrosis factor receptor superfamily, member 14 |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF14, CD270, CD270 antigen, CD40-like protein, Herpesvirus entry mediator, Herpesvirus entry mediator A, HVEM, LIGHTR, Herpes virus entry mediator A, TR2, ATAR, HVEA |
| Target Sequences: | NM_003820 NP_003811.2 Q92956 |
Publications (3)
1
Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability. Cheung TC, Coppieters K, Sanjo H, Oborne LM, Norris PS, Coddington A, Granger SW, Elewaut D, Ware CF. Journal of immunology (Baltimore, Md. : 1950). 2010 185:1949-58.
[PubMed:20592286]
[PMC:PMC2921593]
Related Antibodies: LS-C41150.
2
B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. Hobo W, Norde WJ, Schaap N, Fredrix H, Maas F, Schellens K, Falkenburg JH, Korman AJ, Olive D, van der Voort R, Dolstra H. Journal of immunology (Baltimore, Md. : 1950). 2012 189:39-49.
[PubMed:22634623]
Related Antibodies: LS-C41150.
3
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Ramsay AG, Clear AJ, Fatah R, Gribben JG. Blood. 2012 120:1412-21. (WB; Human)
[Full Text Article]
[PubMed:22547582]
[PMC:PMC3423779]
Related Antibodies: LS-C41150.
☰ Filters
Products
Proteins
(23)
Type
Over-Expression Lysate
(2)
Recombinant
(21)
Target
TNFRSF14 / CD270 / HVEM
(23)
Publications
No
(23)
Tag
DDK (Flag)-His, C-terminus
(1)
Fc, C-terminus
(5)
Fc/His,C-terminus
(1)
GST
(1)
His
(2)
His, C-Terminal
(1)
His, N-Terminal
(1)
His,C-terminus
(2)
His-T7
(1)
mFc, C-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(15)
Monkey-Rhesus
(2)
Mouse
(5)
Source
293T Cells
(1)
E. coli
(4)
HEK 293 Cells
(4)
High Five Cells
(1)
Human
(2)
Human Cells
(1)
Insect Cells
(1)
Mammalian Cells
(7)
Sf9 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(6)
Low Endotoxin Level
Low endotoxin level
(13)
Biologically Active
Biologically active
(4)
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.3 kDa
10 µg/$350; 50 µg/$407
E. coli
His
25.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
High Five Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
20 µg/$268; 100 µg/$349
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.6kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
Wheat Germ Extract
GST
52.8 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$1,107
Human
None
Less than 1.0 EU/µg protein (determined by LAL method).
44.5kD
50 µg/$321; 500 µg/$802; 1 mg/$1,113; 10 µg/$262
293T Cells
Myc-DDK (Flag)
30.42 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
30.42 kDa
100 µg/$494
HEK 293 Cells
DDK (Flag)-His, C-terminus
19 kDa
20 µg/$1,107
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
45.6 kDa
50 µg/$313; 10 µg/$259; 1 mg/$1,470; 500 µg/$1,025
Insect Cells
None
Biologically active
Less than 0.1 ng/µg of protein.
The 376 amino acid recombinant protein consists of an N-terminal domain corresponding to the extracellular domain of HVEM and C-terminal portion corresponding to amino acid 102 to 330 of human IgG1. The protein has a predicted molecular mass of approximat
20 µg/$272; 100 µg/$352
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.5 kDa
10 µg/$262; 50 µg/$317
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.38 kDa
10 µg/$248; 50 µg/$299
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.7 kDa
10 µg/$262; 50 µg/$317
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.6 kDa
10 µg/$248; 50 µg/$288
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.1 kDa
10 µg/$262; 50 µg/$339
E. coli
His-T7
21.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Sf9 Cells
None
Biologically active
~45 kDa (SDS-PAGE)
50 µg/$262; 1 mg/$711
E. coli
His, N-Terminal
22kDa
10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361
HEK 293 Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.4 kDa
100 µg/$600
Human
His, C-Terminal
Less than 0.1 EU/µg protein (determined by LAL method).
18.38kD
10 µg/$248; 50 µg/$299; 500 µg/$725; 1 mg/$1,067
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