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TJP1 / ZO-1

tight junction protein 1

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

Gene Name: tight junction protein 1
Family/Subfamily: Occludin , Not assigned-Occludin
Synonyms: TJP1, ZO-1, Zona occludens protein 1, Zona occludens 1, Zonula occludens protein 1, Tight junction protein 1, ZO1, Tight junction protein ZO-1, Zonula occludens 1 protein
Target Sequences: NM_003257 NP_003248.3 Q07157

Publications (11)

1
A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. PloS one. 2015 10:e0121707. (ICC, IHC-P; Human) [Full Text Article] [PubMed:25826270] [PMC:PMC4380339]
2
Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac. Ai Matsubara, Takenori Miyashita, Ryuhei Inamoto, Hirofumi Sakaguchi, Toru Kamitani, Nozomu Mori, Hiroshi Hoshikawa. The journal of international advanced otology. 2018 August;14:312-316. [Full Text Article] [PubMed:30100545] [PMC:PMC6354451] Related Antibodies: LS-C124822.
3
Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation. Anuj Tharakan, Ashleigh A Halderman, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan Jr. International forum of allergy & rhinology. 2016 November;6:1145-1150. [Full Text Article] [PubMed:27580429] [PMC:PMC5097009] Related Antibodies: LS-C354905.
4
Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. Nora Freyer, Fanny Knöspel, Nadja Strahl, Leila Amini, Petra Schrade, Sebastian Bachmann, Georg Damm, Daniel Seehofer, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger. BioResearch Open Access. 2016 Aug;5:235-48. [Full Text Article] [PubMed:27610270] [PMC:PMC5003005]
5
Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions. Yao-Tseng Wen, Ching-Wen Huang, Chih-Peng Liu, Chih-Hung Chen, Chia-Mu Tu, Chrong-Shiong Hwang, Yi-Hsun Chen, Wan-Ru Chen, Keh-Liang Lin, Yu-Chieh Ho, Ta-Ching Chen , Rong-Kung Tsai. The Breast : official journal of the European Society of Mastology. 2021 May;62:21. [Full Text Article] [PubMed:34015079] [PMC:PMC8142697] Related Antibodies: LS-B9774.
6
Dietary 25-Hydroxyvitamin D3 Supplementation Modulates Intestinal Cytokines in Young Broiler Chickens. Gerardo A Abascal-Ponciano, Samuel F Leiva, Joshua J Flees, Luis P Avila, Jessica D Starkey, Charles W Starkey. Frontiers in veterinary science. 2022 July;9:947276. [Full Text Article] [PubMed:35898543] [PMC:PMC9309538] Related Antibodies: LS-C145545.
7
AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration. Kiyoharu J Miyagishima , Ruchi Sharma , Malika Nimmagadda , Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V Do, Marie-Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C Sharp, Catherine Cukras, Paul A Sieving, Robert B Hufnagel, Nicolas G Bazan, Kathleen Boesze-Battaglia, Sheldon Miller, Kapil Bharti. Communications biology. 2021 December;4:1360. [Full Text Article] [PubMed:34887495] [PMC:PMC8660775] Related Antibodies: LS-B9774.
8
Urothelial cell expansion and differentiation are improved by exposure to hypoxia. Stéphane Chabaud, Ingrid Saba, Clément Baratange, Brice Boiroux, Maude Leclerc, Alexandre Rousseau, Sara Bouhout, Stéphane Bolduc. Journal of tissue engineering and regenerative medicine. 2017 November;11:3090-3099. [Full Text Article] [PubMed:28156053] Related Antibodies: LS-B5625.
9
Induction of Human Umbilical Mesenchymal Stem Cell Differentiation Into Retinal Pigment Epithelial Cells Using a Transwell-Based Co-culture System. Yu-Hsun Chang, V Bharath Kumar, Yao-Tseng Wen, Chih-Yang Huang, Rong-Kung Tsai, Dah-Ching Ding. Cell transplantation. 2022 March;31:9636897221085901. [Full Text Article] [PubMed:35321565] [PMC:PMC8961389] Related Antibodies: LS-B9774.
10
Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery. Sophie Dithmer, Christian Staat, Carolin Müller, Min-Chi Ku, Andreas Pohlmann, Thoralf Niendorf, Nora Gehne, Petra Fallier-Becker, Ágnes Kittel, Fruzsina R Walter, Szilvia Veszelka, Maria A Deli, Rosel Blasig, Reiner F Haseloff, Ingolf E Blasig, Lars Winkler. Annals of the New York Academy of Sciences. 2017 June;1397:169-184. [Full Text Article] [PubMed:28505395] Related Antibodies: LS-C124822.
11
Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Short SS, Wang J, Castle SL, Fernandez GE, Smiley N, Zobel M, Pontarelli EM, Papillon SC, Grishin AV, Ford HR. Laboratory investigation; a journal of technical methods and pathology. 2013 93:1265-75. (WB; Human) [Full Text Article] [PubMed:24126890] Related Antibodies: LS-B2129.
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Antibodies (68)
Primary (68)
TJP1 / ZO-1 (68)
Human (48)
Mouse (29)
Rat (25)
Bat (3)
Chimpanzee (6)
Dog (13)
Gibbon (3)
Guinea pig (12)
Horse (3)
Monkey (8)
Pig (4)
Rabbit (6)
Xenopus (3)
Zebrafish (3)
IHC (34)
IHC-Fr (5)
IHC-P (11)
WB (62)
Flo (3)
ELISA (11)
ICC (3)
IF (16)
IHC-IF (1)
IP (16)
Peptide-ELISA (2)
rabbit (57)
mouse (1)
goat (1)
guinea pig (1)
rabbit-new zealand white (2)
rat (6)
Product Group
IHCPlus (1)
PathPlus Cancer (5)
Ig (1)
IgG (24)
IgG1 (1)
IgG2a,k (6)
monoclonal mc (7)
polyclonal pc (60)
recombinant monoclonal rmc (1)
ZO1-1A12 (1)
AF594 Conjugated (1)
APC (2)
APC Conjugated (5)
Biotin Conjugated (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (32)
aa1-190 (8)
aa23-502 (8)
N-Terminus (4)
aa935-984 (4)
C-Terminus (1)
aa1-296 (1)
aa1178-1527 (1)
aa1328-1362 (1)
aa1570-1600 (1)
aa1574-1748 (1)
aa334-634 (1)
aa463-1109 (1)
aa866-995 (1)
aa950-1000 (1)
No (62)
Yes (6)
TJP1 / ZO-1 Antibody - Human Kidney, Positive Signal in Collecting Tubules: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
TJP1 / ZO-1 Goat anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
300 µg/$460
TJP1 / ZO-1 Antibody - Anti-ZO-1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cancer
TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa935-984) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TJP1 / ZO-1 Antibody - Anti-ZO-1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa935-984) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TJP1 / ZO-1 Antibody - Anti-ZO-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa463-1109) Antibody
Mouse, Dog, Guinea pig, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$485
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Dog, Guinea pig, Rat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,073
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Dog, Guinea pig, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,073
TJP1 / ZO-1 Antibody - Anti-TJP1 / ZO-1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer
TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa1-296) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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TJP1 / ZO-1 Rat anti-Mouse Monoclonal Antibody
Mouse
IHC, IP, WB
Unconjugated
100 µg/$872
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TJP1 / ZO-1 Rat anti-Mouse Monoclonal (FITC) Antibody
Mouse
IHC, IP, WB
FITC Conjugated
100 µl/$1,085
TJP1 / ZO-1 Antibody - TJP1 / ZO-1 antibody Western blot of Rat Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TJP1 / ZO-1 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat
WB
Unconjugated
100 µl/$424
TJP1 / ZO-1 Antibody - TJP1 / ZO-1 antibody Western blot of Rat Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TJP1 / ZO-1 Rabbit anti-Rat Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
TJP1 / ZO-1 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Pig, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TJP1 / ZO-1 Antibody - IF using ZO-1 / TJP1 Antibody, Alexa Fluor® 594, Alexa Fluor® 594 conjugate (ZO1-1A12) This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TJP1 / ZO-1 Mouse anti-Human Monoclonal (aa334-634) (AF594) (ZO1-1A12) Antibody
Dog, Human
ELISA, ICC, IF, WB
AF594 Conjugated
100 µg/$566
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TJP1 / ZO-1 Guinea pig anti-Human Polyclonal Antibody
Mouse, Dog, Human
IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$589
TJP1 / ZO-1 Antibody - TJP1 antibody IHC-paraffin: Human Intestinal Cancer Tissue.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa1178-1527) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TJP1 / ZO-1 Antibody - ZO1 Antibody IHC of formalin-fixed and paraffin-embedded lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa1570-1600) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$854
Select
TJP1 / ZO-1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
IF, IHC, WB
HRP Conjugated
100 µl/$1,073
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa866-995) Antibody
Mouse, Dog, Rat, Human
IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$862
TJP1 / ZO-1 Antibody - Western blot of TJP1 / ZO-1 antibody.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal (aa1-190) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TJP1 / ZO-1 Antibody - Western blot analysis of extracts of various cell lines, using TJP1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 15s.
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TJP1 / ZO-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
TJP1 / ZO-1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
Fast Shipping
TJP1 / ZO-1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
TJP1 / ZO-1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Fast Shipping
TJP1 / ZO-1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Select
TJP1 / ZO-1 Rabbit Recombinant Monoclonal Antibody
ICC, IHC, IHC-IF, IP, WB
Unconjugated
10 µl/$299; 100 µl/$548
TJP1 / ZO-1 Antibody - IHC-P on paraffin sections of mouse epididymis. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen. Primary antibody: dilution 1:500, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.
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TJP1 / ZO-1 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
100 µl/$393
Viewing 1-25 of 68 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).