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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
Gene Name: | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
Synonyms: | TNKS2, PARP-5b, PARP-5c, Tankyrase 2, Tankyrase-2, TNKS-2, PARP5B, PART6, Tankyrase-like protein, Tankyrase-related protein, ARTD6, TNKL, PARP5C, TANK2, Tankyrase II |
Target Sequences: | NM_025235 NP_079511.1 Q9H2K2 |
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