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SMO / Smoothened

smoothened, frizzled class receptor

Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas.

Gene Name:	smoothened, frizzled class receptor
Family/Subfamily:	GPCR , Frizzled
Synonyms:	SMO, Frizzled family member 11, FZD11, Gx, Protein Gx, SMOH, Smoothened, Smoothened homolog
Target Sequences:	NM_005631 NP_005622.1 Q99835

Publications (15)

Vertebrate Smoothened functions at the primary cilium. Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY and Reiter JF. Nature. 2005 437:1018-21. (ICC; Mouse, Dog) [PubMed:16136078] Related Antibodies: LS-A2668, LS-A2666.

Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Wang GY, Wang J, Mancianti ML, Epstein EH Jr. Cancer cell. 2011 19:114-24. (IHC-P; Mouse) [Full Text Article] [PubMed:21215705] [PMC:PMC3061401] Related Antibodies: LS-A2668.

Gastric cancer (GC) patients with hedgehog pathway activation: PTCH1 and GLI2 as independent prognostic factors. Chesnokova LS, Hutt-Fletcher LM. Targeted oncology. 2013 (IHC-P; Human) [PubMed:23371028]

Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro. Dores C, Alpaugh W, Su L, Biernaskie J, Dobrinski I. Cell and tissue research. 2017 April;368:215-223. (Human) [Full Text Article] [PubMed:27841005] [PMC:PMC5495557] Related Antibodies: LS-A2666.

A role for primary cilia in aortic valve development and disease. Toomer KA, Fulmer D, Guo L, Drohan A, Peterson N, Swanson P, Brooks B, Mukherjee R, Body S, Lipschutz JH, Wessels A, Norris RA. Developmental dynamics : an official publication of the American Association of Anatomists. 2017 August;246:625-634. [Full Text Article] [PubMed:28556366] [PMC:PMC5548133] Related Antibodies: LS-A2666.

Sonic hedgehog regulation of human rhabdosphincter muscle:Potential implications for treatment of stress urinary incontinence. Hehemann M, Kalmanek E, Choe S, Dynda D, Hu WY, Quek ML, Harrington DA, Stupp SI, McVary KT, Podlasek CA. Neurourology and urodynamics. 2018 November;37:2551-2559. [Full Text Article] [PubMed:30187971] [PMC:PMC6241312] Related Antibodies: LS-A2666.

Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells. Maha H Jamal, Ane C F Nunes, Nosratola D Vaziri, Ramani Ramchandran, Robert L Bacallao, Andromeda M Nauli, Surya M Nauli. Biochemical pharmacology. 2020 August;178:114056. [Full Text Article] [PubMed:32470549] [PMC:PMC7899243] Related Antibodies: LS-A2666.

Mesothelial mobilization in the developing lung and heart differs in timing, quantity, and pathway dependency. Timo H Lüdtke, Carsten Rudat, Jennifer Kurz, Regine Häfner, Franziska Greulich, Irina Wojahn, Nurullah Aydogdu, Tamrat M Mamo, Marc-Jens Kleppa, Mark-Oliver Trowe, Tobias Bohnenpoll, Makoto Mark Taketo, Andreas Kispert. American journal of physiology. Lung cellular and molecular physiology. 2019 May;316:L767-L783. [Full Text Article] [PubMed:30702346] Related Antibodies: LS-A2668.

Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia. Pablo Iruzubieta, Marta Monzón, Tomás Castiella, Teresa Ramírez, Concepción Junquera. Gastric Cancer : official journal of the international Gastric Cancer Association and the Japanese Gastric Cancer Association. 2019 Jan;23:64-72. [Full Text Article] [PubMed:31267361] Related Antibodies: LS-B4911.

Stromal cells of giant cell tumor of bone show primary cilia in giant cell tumor of bone. Tomás Castiella, Pablo Iruzubieta, Eva Monleón, Mª José Cardiel, Jesús Gómez-Vallejo, Marta Monzón, Mª Concepción Junquera. Microscopy research and technique. 2022 March;85:1065-1074. [Full Text Article] [PubMed:34761465] Related Antibodies: LS-B4911.

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Nielsen SK, M[Character f8]llg[Character e5]rd K, Clement CA, Veland IR, Awan A, Yoder BK, Novak I, Christensen ST. Developmental dynamics : an official publication of the American Association of Anatomists. 2008 Aug;237:2039-52. [Full Text Article] [PubMed:18629868] Related Antibodies: LS-A2668.

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC. Developmental biology. Jan;397:191-202. [Full Text Article] [PubMed:25448692] Related Antibodies: LS-A2668.

Sonic and desert hedgehog signaling in human fetal prostate development. Zhu G, Zhau HE, He H, Zhang L, Shehata B, Wang X, Cerwinka WH, Elmore J, He D. The Prostate. 2007 May;67:674-84. [Full Text Article] [PubMed:17342747] Related Antibodies: LS-A2666.

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Shao YY, Wang L, Welter JF, Ballock RT. Bone. 2012 Jan;50:79-84. [Full Text Article] [PubMed:21930256] [PMC:PMC3246537] Related Antibodies: LS-A2666.

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Varjosalo M, Li SP, Taipale J. Developmental cell. 2009 Feb;10:177-86. [Full Text Article] [PubMed:16459297] Related Antibodies: LS-A2666.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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