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RB1 / Retinoblastoma / RB
retinoblastoma 1
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
| Gene Name: | retinoblastoma 1 |
| Synonyms: | RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110 |
| Target Sequences: | NM_000321 NP_000312.2 P06400 |
Publications (3)
1
Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders. Chen D, Law ME, Theis JD, Gamez JD, Caron LB, Vrana JA, Dogan A. The American journal of surgical pathology. 2009 33:720-9. (IHC)
[PubMed:19145199]
[PMC:PMC2674112]
2
Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas. Ferguson DC, Long DJ, Smith MC, Craig-Owens LD, Means J, Fadare O, Desouki MM. Journal of ovarian research. 2015 8:34. (WB; Human)
[Full Text Article]
[PubMed:26043844]
[PMC:PMC4459058]
3
Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics. Laura Atzori, Luca Pilloni, Ramona Zanniello, Caterina Ferreli, Franco Rongioletti. Journal of cutaneous pathology. 2020 June;47:571-575. [Full Text Article]
[PubMed:31999365]
Related Antibodies: LS-C339687.
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Type
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(278)
Target
RB1 / Retinoblastoma / RB
(278)
Reactivity
Human
(271)
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(105)
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(91)
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(7)
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(15)
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(9)
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(9)
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(6)
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Publications
No
(277)
Yes
(1)
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa309-590) (OTI3F11) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa886-905) (3C8) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$475
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (3H9) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$436
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (1F8) Antibody
Human
IHC, IP, WB
Unconjugated
0.1 ml/$313; 0.5 ml/$634; 1 ml/$990
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa393-572) Antibody
Chicken, Mouse, Rat, Human
IP, WB
Unconjugated
100 µg/$466
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (aa858-886) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (pThr821) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa309-590) (OTI1C3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC
Unconjugated
250 µl/$490
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa511-530) (1E5) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$462
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (7E4B8) Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$339
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (pSer780) Antibody
Dog, Bovine, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (aa196-245) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
Cancer
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (aa552-601) Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
RB1 / Retinoblastoma / RB Mouse anti-Human Monoclonal (aa309-590) (Carrier-free) (OTI13A6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (pSer608) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (pSer780) Antibody
Human
DB, IHC, IHC-P
Unconjugated
400 µl/$393
RB1 / Retinoblastoma / RB Rabbit anti-Zebrafish Polyclonal Antibody
Fish, Zebrafish
ELISA, WB
Unconjugated
250 µl/$691
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (aa781-830) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$341
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$341
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (PSer249/Thr252) Antibody
Mouse, Rat, Human
WB
Unconjugated
25 µg/$351
RB1 / Retinoblastoma / RB Rabbit anti-Human Polyclonal (pThr821) Antibody
Mouse, Rat, Human
WB
Unconjugated
25 µg/$351
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