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PML

promyelocytic leukemia

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration.Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HCMV) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription.

Gene Name: promyelocytic leukemia
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: PML, PP8675, Promyelocytic leukemia, Protein PML, TRIM19, Promyelocytic leukemia protein, RING finger protein 71, MYL, RNF71
Target Sequences: NM_002675 NP_002666.1 P29590

☰ Filters
Antibodies (61)
Proteins (15)
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Over-Expression Lysate (10)
Primary (61)
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PML (78)
Human (54)
Mouse (16)
Rat (7)
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IHC (28)
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WB (58)
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ELISA (12)
ICC (11)
IF (12)
IP (4)
Peptide-ELISA (2)
rabbit (51)
mouse (10)
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monoclonal mc (10)
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aa59-239 (8)
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30-110 aa, N-terminal (1)
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PML Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PML Rabbit anti-Human Polyclonal (aa470-499) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PML Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PML Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PML Antibody - Immunofluorescence of monoclonal antibody to PML on HeLa cell. [antibody concentration 10 ug/ml]
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PML Mouse anti-Human Monoclonal (1D12) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
PML Antibody - Anti-PML antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PML Rabbit anti-Human Polyclonal (aa588-637) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PML Antibody - Immunohistochemical analysis of PML staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PML Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
PML Antibody - Western blot of recombinant PML.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PML Rabbit anti-Human Polyclonal (aa59-239) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
PML Antibody - 1:100 staining human kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PML Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PML Antibody
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PML Mouse anti-Human Monoclonal (1B9) Antibody
Human
Flo, ICC, IP, WB
Unconjugated
100 µg/$423
PML Antibody - Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using PML Antibody. The picture on the right is blocked with the synthesized peptide.
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PML Rabbit anti-Human Polyclonal (aa11-60) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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PML Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PML Antibody - Western blot of PML antibody
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PML Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PML Antibody - IHC of PML (P39) pAb in paraffin-embedded human tonsil thyroid tissue.
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PML Rabbit anti-Human Polyclonal (Pro39) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PML Antibody - Anti-PML rabbit polyclonal antibody at 1:500 dilution. Lane A: A549 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 48-98 kDa. Observed band size: 85 kDa. (We are unsure as to the identity of these extra bands.)
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PML Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
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PML Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µg/$533
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PML Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P
Unconjugated
100 µl/$412
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PML Rabbit anti-Human Polyclonal (aa470-499) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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PML Rabbit anti-Human Polyclonal (aa470-499) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PML Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
PML Antibody - PML Protein was detected in paraffin-embedded sections of human intetsinal cancer tissues using rabbit anti- PML Protein Antigen Affinity purified polyclonal antibody
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PML Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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PML Mouse anti-Mouse Monoclonal (aa1-581) Antibody
Mouse
ICC, WB
Unconjugated
200 µg/$832
PML Antibody - PML Protein was detected in paraffin-embedded sections of mouse spleen tissues using rabbit anti- PML Protein Antigen Affinity purified polyclonal antibody
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PML Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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PML Rabbit anti-Human Polyclonal Antibody
Human
ChIP-Seq, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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PML Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
PML Antibody - Detection of Human PML by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PML used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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PML Rabbit anti-Human Polyclonal (aa375-425) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PML Antibody - Detection of Human PML by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PML used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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PML Rabbit anti-Human Polyclonal (aa575-625) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 78 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).