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PDGF-BB
platelet-derived growth factor beta polypeptide
PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
| Gene Name: | platelet-derived growth factor beta polypeptide |
| Family/Subfamily: | PDGF , not assigned-PDGF |
| Synonyms: | PDGFB, PDGF-BB, PDGF-b, SSV, PDGF subunit B, PDGF-2, PDGF2, Proto-oncogene c-Sis, SIS, C-sis, PDGF, B chain |
| Target Sequences: | NM_002608 NP_002599.1 P01127 |
Publications (5)
1
Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease. Samy Hakroush, Marcus J. Moeller, Franziska Theilig, Brigitte Kaissling, Tjeerd P. Sijmonsma, Manfred Jugold, Ann L. Akeson, Milena Traykova-Brauch, Hiltraud Hosser, Brunhilde Hähnel, Hermann-Josef Gröne, Robert Koesters, and Wilhelm Kriz. The American journal of pathology. 2009 275:1883-95. (IHC-P; Mouse)
[Full Text Article]
[PubMed:19834063]
[PMC:PMC2774053]
2
Severe renal mass reduction impairs recovery and promotes fibrosis after AKI. Polichnowski AJ, Lan R, Geng H, Griffin KA, Venkatachalam MA, Bidani AK. Journal of the American Society of Nephrology : JASN. 2014 25:1496-507. (WB; Human)
[Full Text Article]
[PubMed:24511135]
[PMC:PMC4073422]
3
Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease. Ana M Porras, Jennifer A Westlund, Austin D Evans, Kristyn S Masters. Proceedings of the National Academy of Sciences of the United States of America. 2018 January;115:E363-E371. [Full Text Article]
[PubMed:29282325]
[PMC:PMC5776956]
Related Antibodies: LS-B4182.
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PDGF-BB Goat anti-Human Polyclonal (aa222-233) Antibody
Sheep, Bovine, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
PDGF-BB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDGF-BB Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Bat, Rat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
PDGF-BB Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
PDGF-BB Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$842
PDGF-BB Mouse anti-Human Monoclonal (aa82-190) Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
PDGF-BB Mouse anti-Human Monoclonal (aa82-190) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$342; 200 µl/$399; 500 µl/$587; 1 ml/$725; 2 ml/$962; 5 ml/$1,647
PDGF-BB Mouse anti-Human Monoclonal (aa82-190) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$399; 200 µl/$479; 500 µl/$822; 1 ml/$978; 2 ml/$1,255; 5 ml/$2,353
PDGF-BB Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDGF-BB Rabbit anti-Mouse Polyclonal (aa21-241) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
PDGF-BB Rabbit anti-Rat Polyclonal (aa5-225) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
PDGF-BB Rabbit anti-Human Polyclonal (aa16-65) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PDGF-BB Rabbit anti-Human Polyclonal (aa212-241) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
PDGF-BB Rabbit anti-Human Polyclonal (aa82-190) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
PDGF-BB Rabbit anti-Human Polyclonal (aa212-241) Antibody
Human
ICC, IF, WB
Unconjugated
400 µl/$393
PDGF-BB Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
0.1 mg/$579
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PDGF-BB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µg/$442
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