NOTCH1

notch 1

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NOTCH1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His,C-terminus (2)

Human IgG1 Fc (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (3)

Source

293T Cells (1)

CHO Cells (1)

HEK 293 Cells (1)

Insect Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (3)

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Human NOTCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90569

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

272.58 kDa

Price:

20 µg/$215

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Human NOTCH1 Protein (Recombinant GST, N-terminus) (aa23-132) - LS-G59425

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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NOTCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101485

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

272.58 kDa

Price:

100 µg/$710

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Mouse NOTCH1 Protein (Recombinant His,C-terminus) (Met1-Gln526) - LS-G138144

Source:

Insect Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55 kDa

Price:

50 µg/$483

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Mouse NOTCH1 Protein (Recombinant His,C-terminus) (Ala18-Gln526) - LS-G139378

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54.4 kDa

Price:

10 µg/$281; 50 µg/$389

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Mouse NOTCH1 Protein (Recombinant Human IgG1 Fc) (aa19-488) - LS-G3941

Source:

CHO Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~85kDa (SDS-PAGE)

Price:

50 µg/$379

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