NOTCH1 is a transmembrane receptor that binds Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. These include a number of functions in the brain, such as promoting progenitor cell differentiation into astrocytes and repressing neuronal and myogenic differentiation. NOTCH1 is also involved in angiogenesis, and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. During cerebellar development, NOTCH1 functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. In immunohistochemistry, NOTCH1 has positivity in most tissues throughout the body. References: Neuron. 29 (1): 45–55, PMID: 11182080; Neuron. 26 (2): 395–404, PMID: 10839358; Neuron. 26 (2): 395–404, PMID: 10839358;