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MYB / c-Myb

v-myb avian myeloblastosis viral oncogene homolog

MYB / c-Myb is a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.

Gene Name: v-myb avian myeloblastosis viral oncogene homolog
Synonyms: MYB, C-myb_CDS, C-myb8B_CDS, C-myb protein (140 AA), C-myb10A_CDS, C-myb13A_CDS, Efg, Transcriptional activator Myb, C-myb, C-myb14A_CDS, Cmyb, Proto-oncogene c-Myb
Target Sequences: NM_005375 NP_005366.2 P10242

Publications (4)

1
Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome. Hussein K, Theophile K, Bsche G, Schlegelberger B, Ghring G, Kreipe H, Bock O. Leukemia research. 2010 34:328-34. (IHC) [PubMed:19615744]
2
The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin. Kaspar P, Zikova M, Bartunek P, Sterba J, Strnad H, Kren L, Sedlacek R. Scientific reports. 2015 5:15090. (IHC; Mouse) [Full Text Article] [PubMed:26462877] [PMC:PMC4604482] Related Antibodies: LS-B5315.
3
Aberrant expression of AID and AID activators of NF-?B and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers. Mohri T, Nagata K, Kuwamoto S, Matsushita M, Sugihara H, Kato M, Horie Y, Murakami I, Hayashi K. Oncology letters. 2017 13:4133-4140. (ICC; Human) [Full Text Article] [PubMed:28588701] [PMC:PMC5452920]
4
Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas. Matsushita M, Iwasaki T, Nonaka D, Kuwamoto S, Nagata K, Kato M, Kitamura Y, Hayashi K. Yonago acta medica. 2017 September;60:145-153. [Full Text Article] [PubMed:28959124] [PMC:PMC5611468]
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Products
Antibodies (85)
Primary (85)
MYB / c-Myb (85)
Human (71)
Mouse (57)
Rat (1)
Bat (4)
Bovine (4)
Chicken (3)
Chimpanzee (3)
Dog (2)
Gibbon (3)
Guinea pig (3)
Horse (5)
Monkey (5)
Pig (5)
Rabbit (4)
Xenopus (1)
Zebrafish (3)
IHC (33)
IHC-P (20)
WB (77)
Flo (2)
ELISA (23)
ICC (2)
IF (6)
IP (13)
Peptide-ELISA (8)
rabbit (67)
mouse (14)
goat (3)
sheep (1)
Product Group
IHCPlus (4)
IgG (35)
IgG1,k (3)
IgG2a (5)
IgG2a,k (6)
monoclonal mc (14)
polyclonal pc (71)
10A3 (1)
1279CT309.289 (1)
MYB286 (2)
APC (2)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (9)
BSA-free (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (6)
Unconjugated (43)
C-Terminus (13)
aa305-558 (8)
aa35-291 (8)
aa419-448 (7)
aa26-75 (4)
pSer532 (4)
Internal (2)
aa119-135 (2)
pSer12 (2)
pThr486 (2)
1-80 aa (1)
470-550 aa (1)
Arg6 (1)
Ile526 (1)
N-Terminus (1)
aa1-185 (1)
aa1-201 (1)
aa1-50 (1)
aa241-254 (1)
aa281-294 (1)
aa496-545 (1)
aa503-552 (1)
aa557-569 (1)
aa591-640 (1)
p12 (1)
p532 (1)
No (84)
Yes (1)
MYB / c-Myb Antibody - Anti-c-Myb antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
MYB / c-Myb Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MYB / c-Myb Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MYB / c-Myb Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa26-75) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MYB / c-Myb Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa26-75) (Biotin) Antibody
Chicken, Zebrafish, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
MYB / c-Myb Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa26-75) (FITC) Antibody
Chicken, Zebrafish, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
MYB / c-Myb Antibody - IHC of MYB (R6) pAb in paraffin-embedded human breast carcinoma tissue.
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MYB / c-Myb Rabbit anti-Human Polyclonal (Arg6) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
MYB / c-Myb Antibody - Goat anti-MYB / c-myb Antibody (2µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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MYB / c-Myb Goat anti-Human Polyclonal (aa281-294) Antibody
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
MYB / c-Myb Antibody - Anti-C-Myb Antibody - Western Blot. Western blot of affinity purified anti-C-Myb antibody in Cos7 cell lysates: Lane 1: vector; Lane 2: transfected with c-myb, no treatment; Lane 3: transfected with c-Myb and heat stress-treated (incubation at 42oC for 30 minutes) to induce c-Myb modification. Lane 3 shows detection of bands at 75, 98, and 125kD corresponding to overexpressed c-Myb (arrows): wild-type, with one attached SUMO molecule, and with two attached SUMO molecules, respectively. Nitrocellulose 0.45mum membrane was blocked for 1 hr at RT in 10% BLOTTO in PBS. The primary antibody was used at 1:500. Personal communication, J. Bies, NCI NIH, Bethesda.
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MYB / c-Myb Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$567
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MYB / c-Myb Mouse anti-Human Monoclonal (aa119-135) (MYB286) Antibody
Human
Flo
Unconjugated
20 µg/$371; 100 µg/$574
MYB / c-Myb Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MYB (Ab-12) antibody.
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MYB / c-Myb Rabbit anti-Human Polyclonal (p12) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MYB / c-Myb Antibody - 1:100 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MYB / c-Myb Rabbit anti-Human Polyclonal (pSer532) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MYB / c-Myb Antibody - Anti-c-Myb antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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MYB / c-Myb Goat anti-Human Polyclonal (aa241-254) Antibody
Rabbit, Dog, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µl/$734
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
200 µl/$952
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
200 µl/$952
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
APC Conjugated
200 µl/$952
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
HRP Conjugated, Azide-free
200 µl/$952
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MYB / c-Myb Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
PE Conjugated
200 µl/$952
MYB / c-Myb Antibody - Immunohistochemistry analysis of paraffin-embedded human heart, using MYB (Phospho-Ser12) Antibody. The picture on the right is blocked with the phospho peptide.
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MYB / c-Myb Rabbit anti-Human Polyclonal (pSer12) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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MYB / c-Myb Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa419-448) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
MYB / c-Myb Antibody - Western blot of recombinant MYB / c-Myb.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa305-558) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
MYB / c-Myb Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human heart tissue using MYB (Phospho-Ser12) antibody.
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MYB / c-Myb Rabbit anti-Human Polyclonal (pSer12) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
MYB / c-Myb Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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MYB / c-Myb Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MYB / c-Myb Antibody - MYB Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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MYB / c-Myb Rabbit anti-Human Polyclonal (aa419-448) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).