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MSLN / Mesothelin
mesothelin
This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. Mesothelin null mutant mice show a normal phenotype suggesting that mesothelin function is not essential for growth or reproduction in mice (Bera et al., 2000).
| Gene Name: | mesothelin |
| Synonyms: | MSLN, CAK1 antigen, MPF, SMRP, Mesothelin, CAK1 |
| Target Sequences: | NM_013404 NP_037536.2 Q13421 |
Publications (5)
1
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 11:5840-6.
[PubMed:16115924]
Related Antibodies: LS-C154007.
2
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express a-gal epitopes. Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. PloS one. 2017 12:e0184901. (IHC-P; Human)
[Full Text Article]
[PubMed:29077749]
3
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. Watanabe K, Luo Y, Da T, Guedan S, Ruella M, Scholler J, Keith B, Young RM, Engels B, Sorsa S, Siurala M, Havunen R, Tähtinen S, Hemminki A, June CH. JCI insight. 2018 April;3:pii: 99573. (Mouse)
[Full Text Article]
[PubMed:29618658]
[PMC:PMC5928866]
Related Antibodies: LS-C179484.
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(106)
Type
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(106)
Target
MSLN / Mesothelin
(106)
Reactivity
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(88)
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(23)
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(5)
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(2)
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(22)
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(19)
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(81)
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(40)
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(2)
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(58)
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(45)
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(5)
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(38)
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(20)
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(12)
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(4)
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(2)
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(15)
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(2)
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(8)
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(2)
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(2)
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(8)
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(8)
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(4)
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(6)
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(63)
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aa270-493
(16)
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(8)
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(4)
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(4)
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(2)
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(1)
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(1)
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(1)
aa464-563
(1)
Publications
No
(103)
Yes
(3)
MSLN / Mesothelin Mouse anti-Human Monoclonal (MB-G10) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$574
MSLN / Mesothelin Mouse anti-Human Monoclonal (MN-1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa308-576) Antibody
Mouse
IHC, IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
MSLN / Mesothelin Rat anti-Mouse Monoclonal (B35) Antibody
Mouse
Flo
Unconjugated
100 µg/$447
MSLN / Mesothelin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa540-589) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa540-589) (HRP) Antibody
Mouse, Guinea pig, Bovine, Pig, Gibbon, Human
WB
HRP Conjugated
100 µl/$469
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa345-548) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa345-548) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
MSLN / Mesothelin Rat anti-Human Monoclonal Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$951
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa 37-598) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
MSLN / Mesothelin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC, IHC-P
Unconjugated
100 µg/$575
MSLN / Mesothelin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IP, WB
Biotin Conjugated
100 µl/$904
MSLN / Mesothelin Goat anti-Human Polyclonal (aa302-314) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$424
MSLN / Mesothelin Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MSLN / Mesothelin Rabbit anti-Human Monoclonal (YP158) Antibody
Human
IHC
Unconjugated
0.1 ml/$279; 0.5 ml/$479; 1 ml/$711
MSLN / Mesothelin Rabbit anti-Human Monoclonal (YP158) Antibody
Human
IHC
Unconjugated
6 ml/$357
MSLN / Mesothelin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA
Biotin Conjugated, Preservative Free
50 µg/$343
MSLN / Mesothelin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
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