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ME1 / Malate Dehydrogenase encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Gene Name: | malic enzyme 1, NADP(+)-dependent, cytosolic |
Synonyms: | ME1, HUMNDME, Malate dehydrogenase, Malic enzyme 1, Malate oxidoreductase, Malic enzyme 1, soluble, MES, NADP-ME, Pyruvic-malic carboxylase, NADP-dependent malic enzyme, Malic enzyme, cytoplasmic |
Target Sequences: | NM_002395 NP_002386.1 P48163 |
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