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MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
| Gene Name: | MDM2 oncogene, E3 ubiquitin protein ligase |
| Synonyms: | MDM2, ACTFS, Double minute 2 protein, Hdm2, MDM2 variant FB30, HDMX, Oncoprotein Mdm2, p53-binding protein Mdm2, MDM2 variant FB28 |
| Target Sequences: | NM_002392 NP_002383.2 Q00987 |
Publications (3)
1
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse)
[Full Text Article]
[PubMed:28249000]
[PMC:PMC5332108]
Related Antibodies: LS-C199239.
2
Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors. Malchenko S, Sredni ST, Boyineni J, Bi Y, Margaryan NV, Guda MR, Kostenko Y, Tomita T, Davuluri RV, Velpula K, Hendrix MJC, Soares MB. Oncotarget. 2018 February;9:13733-13747. (Human)
[Full Text Article]
[PubMed:29568390]
[PMC:PMC5862611]
Related Antibodies: LS-C199239.
3
Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors. Irina Alimova, Dong Wang, Etienne Danis, Angela Pierce, Andrew Donson, Natalie Serkova, Krishna Madhavan, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Nicholas K Foreman, Siddhartha Mitra, Sujatha Venkataraman, Rajeev Vibhakar. International journal of oncology. 2022 March;60:32. [Full Text Article]
[PubMed:35179215]
[PMC:PMC8878716]
Related Antibodies: LS-C199239.
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Products
Antibodies
(158)
Type
Primary
(158)
Target
MDM2
(158)
Reactivity
Human
(153)
Mouse
(54)
Rat
(31)
Bovine
(1)
Dog
(2)
Gibbon
(1)
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(1)
Monkey
(9)
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(1)
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(1)
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IHC
(74)
IHC-Fr
(4)
IHC-P
(28)
WB
(120)
DB
(14)
ELISA
(50)
ICC
(5)
IF
(27)
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(1)
IP
(10)
Peptide-ELISA
(8)
Host
rabbit
(101)
mouse
(56)
goat
(1)
Product Group
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(3)
Isotype
IgG
(61)
IgG1
(40)
IgG1,k
(6)
IgG2a
(4)
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(4)
IgG2b,k
(1)
Clonality
monoclonal mc
(56)
polyclonal pc
(102)
Clone
1806CT309.52.1
(1)
1A7
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OTI15C5
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(2)
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(2)
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(2)
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(2)
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(2)
SMP14
(2)
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(1)
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(1)
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(7)
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(1)
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(1)
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(1)
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(5)
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(9)
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(1)
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(20)
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(1)
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(1)
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(9)
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(8)
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(1)
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(7)
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(1)
Ready-to-Use
(2)
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(1)
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(1)
Unconjugated
(108)
Epitope
aa119-438
(38)
pSer166
(9)
aa1-321
(8)
Ser166
(7)
aa393-424
(7)
pSer395
(7)
pThr218
(7)
Internal
(5)
110-190 aa
(2)
120-200 aa
(2)
C-Terminus
(2)
aa103-119
(2)
360-440 aa, C-terminal
(1)
381-430 aa, C-terminal
(1)
Ab-186/188
(1)
Phe414
(1)
Ser160
(1)
Tyr394
(1)
aa132-181
(1)
aa151-200
(1)
aa154-167
(1)
aa177-195
(1)
aa179-193
(1)
aa26-169
(1)
aa343-358
(1)
aa391-440
(1)
aa418-432
(1)
p166
(1)
pSer185
(1)
pSer186
(1)
pSer186+Ser188
(1)
pSer260
(1)
pTyr394
(1)
Publications
No
(157)
Yes
(1)
MDM2 Mouse anti-Human Monoclonal (aa154-167) (SMP14) Antibody
Human
IHC, IHC-Fr, IHC-P, IHC-R
Unconjugated
50 µg/$460
MDM2 Mouse anti-Human Monoclonal (1A7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MDM2 Rabbit anti-Mouse Polyclonal (aa177-195) Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$448
MDM2 Mouse anti-Human Monoclonal Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$340
MDM2 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
MDM2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MDM2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rat, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$321
MDM2 Rabbit anti-Human Polyclonal (pSer395) Antibody
Human
DB, IHC, IHC-P
Unconjugated
200 µl/$440
MDM2 Mouse anti-Human Monoclonal (aa26-169) Antibody
Human
IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$778
MDM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
![MDM2 Antibody - Anti-MDM2 Antibody - Western Blot. Western blot using affinity purified Anti-MDM2 (Rabbit) is shown to detect a band (arrow) corresponding to mouse MDM2 protein present in mouse MEF cells (lane 2) but not human kidney HEK293 cells (lane 1). Approximately 35 ug of lysate was separated by 4-20% Tris Glycine SDS-PAGE. After blocking the membrane with 5% normal goat serum, 0.5% BLOTTO in PBS, the membrane was probed for overnight at 4° with the primary antibody diluted to 1:500 in 1% normal goat serum, 0.1% BLOTTO in PBS. The membrane was washed and reacted with a 1:10000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] ( for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers indicated at the right (700 nm channel, red). IRDye800 fluorescence image was captured using the Ddyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.](https://lsbio-7d62.kxcdn.com/image2/mdm2-antibody-ls-c19046/62938_910982.jpg)
MDM2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$567
MDM2 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Human
IHC, IP, WB
PE Conjugated
100 µl/$848
MDM2 Mouse anti-Human Monoclonal (Tyr394) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MDM2 Goat anti-Human Polyclonal (aa179-193) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
MDM2 Rabbit anti-Human Polyclonal (pSer166) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
MDM2 Rabbit anti-Human Polyclonal (pSer166) Antibody
Mouse, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MDM2 Rabbit anti-Human Polyclonal (aa103-119) Antibody
Rat, Human
WB
Unconjugated
100 µg/$380
MDM2 Rabbit anti-Human Polyclonal (pSer260) Antibody
WB
Unconjugated
20 µl/$287; 100 µl/$431
MDM2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MDM2 Rabbit anti-Human Polyclonal (pSer166) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MDM2 Rabbit anti-Human Polyclonal (pSer166) Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
MDM2 Rabbit anti-Human Polyclonal (Ser166) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MDM2 Rabbit anti-Human Polyclonal (aa391-440) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MDM2 Rabbit anti-Human Polyclonal (110-190 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MDM2 Rabbit anti-Human Polyclonal (pSer166) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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