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MAP1LC3B / LC3B

microtubule-associated protein 1 light chain 3 beta

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Name:	microtubule-associated protein 1 light chain 3 beta
Synonyms:	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B-a
Target Sequences:	NM_022818 NP_073729.1 Q9GZQ8

Publications (55)

Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK. Autophagy. 2008 4:315-21. [PubMed:18196969]

Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Autophagy. 2008 4:467-75. (ICC, WB, IHC-Fr; Mouse) [PubMed:18259115]

Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Overmeyer JH, Kaul A, Johnson EE, Maltese WA. Molecular cancer research : MCR. 2008 6:965-77. [PubMed:18567800] [PMC:PMC2994605] Related Antibodies: LS-C165711.

Induction of autophagic cell death by a novel molecule is increased by hypoxia. Tafani M, Schito L, Anwar T, Indelicato M, Sale P, Di Vito M, Morgante E, Beraldi R, Makovec F, Letari O, Caselli G, Spadafora C, Pucci B, Russo MA. Autophagy. 2008 4:1042-53. (ICC, WB; Human) [PubMed:18927491]

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE. Human molecular genetics. 2009 18:1937-50. (ICC, WB; Mouse) [PubMed:19279159] [PMC:PMC2678926]

Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M. The American journal of pathology. 2009 174:1891-909. (ICC, WB; Human) [PubMed:19349362] [PMC:PMC2671277]

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. The American journal of pathology. 2009 175:736-47. [PubMed:19628769] [PMC:PMC2716969]

5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. Liu MT, Kuan YH, Wang J, Hen R, Gershon MD. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:9683-99. (ICC; Mouse) [PubMed:19657021] [PMC:PMC2749879]

Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. Wartosch L, Fuhrmann JC, Schweizer M, Stauber T, Jentsch TJ. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 23:4056-68. [PubMed:19661288] Related Antibodies: LS-C165711.

Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Human molecular genetics. 2010 19:2445-55. [PubMed:20354076] [PMC:PMC2876889]

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR. Human molecular genetics. 2011 20:40-50. [PubMed:20940149] [PMC:PMC3000675]

Enhanced activation of autophagy in -thalassemia/Hb E erythroblasts during erythropoiesis. Lithanatudom P, Wannatung T, Leecharoenkiat A, Svasti S, Fucharoen S, Smith DR. Annals of hematology. 2011 90:747-58. (ICC, WB; Human) [PubMed:21221583]

Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL. Human molecular genetics. 2011 20:1820-33. [PubMed:21320871]

JNK regulates FoxO-dependent autophagy in neurons. Xu P, Das M, Reilly J, Davis RJ. Genes & development. 2011 25:310-22. [PubMed:21325132] [PMC:PMC3042155]

Pancreatic cancers require autophagy for tumor growth. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Genes & development. 2011 25:717-29. [PubMed:21406549] [PMC:PMC3070934]

Inflammasome-independent modulation of cytokine response by autophagy in human cells. Crian TO, Plantinga TS, van de Veerdonk FL, Farca MF, Stoffels M, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG. PloS one. 2011 6:e18666. [PubMed:21490934] [PMC:PMC3072416]

PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 17:5353-66. [PubMed:21690574]

Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Castino R, Fiorentino I, Cagnin M, Giovia A, Isidoro C. Toxicological sciences : an official journal of the Society of Toxicology. 2011 123:523-41. [PubMed:21742779] [PMC:PMC3218672]

Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Journal of virology. 2011 85:10561-71. [PubMed:21835792] [PMC:PMC3187495] Related Antibodies: LS-C165711.

Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells. Sobolewska A, Motyl T, Gajewska M. European journal of cell biology. 2011 90:854-64. [PubMed:21868124]

Impaired cardiac autophagy in patients developing postoperative atrial fibrillation. Garcia L, Verdejo HE, Kuzmicic J, Zalaquett R, Gonzalez S, Lavandero S, Corbalan R. The Journal of thoracic and cardiovascular surgery. 2012 143:451-9. [PubMed:21885071]

Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses. Morris S, Swanson MS, Lieberman A, Reed M, Yue Z, Lindell DM, Lukacs NW. Journal of immunology (Baltimore, Md. : 1950). 2011 187:3953-61. [PubMed:21911604] [PMC:PMC3186849]

Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. PLoS genetics. 2011 7:e1002321. [PubMed:22022281] [PMC:PMC3192827]

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, Pags G, Pouyssgur J, McGargill MA, Green DR, Kanneganti TD. The Journal of biological chemistry. 2011 286:42981-91. [PubMed:22033934] [PMC:PMC3234870]

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Autophagy. 2012 8:609-22. [PubMed:22361619] [PMC:PMC3405840]

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages. Kawano A, Tsukimoto M, Mori D, Noguchi T, Harada H, Takenouchi T, Kitani H, Kojima S. Biochemical and biophysical research communications. 2012 420:102-7. (WB; Mouse) [PubMed:22405772]

Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, Wu MC, Wei LX. Cancer letters. 2012 320:171-9. (WB; Human) [PubMed:22406827]

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. Human molecular genetics. 2012 21:2651-62. (WB; Human) [PubMed:22437840] [PMC:PMC3363339]

Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells. Delk NA, Farach-Carson MC. Autophagy. 2012 8:650-63. [PubMed:22441019] [PMC:PMC3405839]

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. The Journal of experimental medicine. 2012 209:855-69. (WB; Human) [PubMed:22473955] [PMC:PMC3328359]

miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A. Gastroenterology. 2012 143:177-87.e8. (WB; Human) [PubMed:22504094]

BNip3 regulates mitochondrial function and lipid metabolism in the liver. Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW, Brady MJ, Macleod KF. Molecular and cellular biology. 2012 32:2570-84. (WB; Mouse) [PubMed:22547685] [PMC:PMC3434502]

Amyloid- secretion, generation, and lysosomal sequestration in response to proteasome inhibition: involvement of autophagy. Agholme L, Hallbeck M, Benedikz E, Marcusson J, Kgedal K. Journal of Alzheimer's disease : JAD. 2012 31:343-58. [PubMed:22555375]

MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:3030-41. (WB; Human) [PubMed:22619307]

A quantitative TR-FRET plate reader immunoassay for measuring autophagy. Hancock MK, Hermanson SB, Dolman NJ. Autophagy. 2012 8:1227-44. [PubMed:22622129]

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:7454-65. [PubMed:22649225] [PMC:PMC3454486] Related Antibodies: LS-C165711.

Caspase activation regulates the extracellular export of autophagic vacuoles. Sirois I, Groleau J, Pallet N, Brassard N, Hamelin K, Londono I, Pshezhetsky AV, Bendayan M, Hbert MJ. Autophagy. 2012 8:927-37. [PubMed:22692030] [PMC:PMC3427258]

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:11008-13. (ICC, IHC; Mouse) [PubMed:22715292] [PMC:PMC3390880]

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Cancer research. 2012 72:3938-47. [PubMed:22719070] Related Antibodies: LS-C165711.

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Lai AY, McLaurin J. Biochimica et biophysica acta. 2012 1822:1629-37. (WB; Mouse) [PubMed:22800931]

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. Gal J, Bang Y, Choi HJ. Neurochemistry international. 2012 61:992-1000. (WB; Human) [PubMed:22819792]

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. PloS one. 2012 7:e41831. (ICC, WB; Human) [PubMed:22848625] [PMC:PMC3406086]

Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Elrick MJ, Yu T, Chung C, Lieberman AP. Human molecular genetics. 2012 21:4876-87. (ICC, IHC; Mouse) [PubMed:22872701] [PMC:PMC3607480]

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung AL, Bradner JE, Weinstock DM. Blood. 2012 120:2843-52. [PubMed:22904298] [PMC:PMC3466965]

Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines. Gwak HS, Kim TH, Jo GH, Kim YJ, Kwak HJ, Kim JH, Yin J, Yoo H, Lee SH, Park JB. PloS one. 2012 7:e47449. (WB; Human) [PubMed:23077620] [PMC:PMC3471817]

Proliferative and survival effects of PUMA promote angiogenesis. Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X. Cell reports. 2012 2:1272-85. (ICC, WB; Mouse) [PubMed:23122957]

UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Bess AS, Ryde IT, Hinton DE, Meyer JN. Journal of biochemical and molecular toxicology. 2013 27:28-41. (WB; Human) [PubMed:23132756]

An autophagy-independent role for LC3 in equine arteritis virus replication. Monastyrska I, Ulasli M, Rottier PJ, Guan JL, Reggiori F, de Haan CA. Autophagy. 2013 9:164-74. [PubMed:23182945] [PMC:PMC3552881]

Immunohistochemical analysis of macroautophagy: recommendations and limitations. Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR. Autophagy. 2013 9:386-402. (ICC; Human) [Full Text Article] [PubMed:23242143] [PMC:PMC3590258]

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Nature. 2013 493:679-83. (WB; Mouse) [PubMed:23263183]

Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. Humbert M, Medov M, Aebersold DM, Blaukat A, Bladt F, Fey MF, Zimmer Y, Tschan MP. Biochemical and biophysical research communications. 2013 431:264-9. (WB; Human) [PubMed:23313490]

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N Neigh, Donald G Stein. International journal of molecular sciences. 2020 May;21: [Full Text Article] [PubMed:32466385] [PMC:PMC7312827]

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma. Claudio Festuccia, Andrea Mancini, Alessandro Colapietro, Giovanni Luca Gravina, Flora Vitale, Francesco Marampon, Simona Delle Monache, Simona Pompili, Loredana Cristiano, Antonella Vetuschi, Vincenzo Tombolini, Yi Chen, Thomas Mehrling. Journal of hemotology & oncology. 2018 February;11:32. [Full Text Article] [PubMed:29486795] [PMC:PMC5830080]

A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway. Chia-Ling Hsieh, Hsu-Shan Huang, Kuan-Chou Chen, Teigi Saka, Chih-Ying Chiang, Leland W K Chung, Shian-Ying Sung. Molecular cancer therapeutics. 2019 Jan;19:101-111. [Full Text Article] [PubMed:31530650] Related Antibodies: LS-B9807.

Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein. Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. American journal of hematology. 2013 [PubMed:23440701] Related Antibodies: LS-C165711.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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