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LTBR is a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Gene Name: | lymphotoxin beta receptor (TNFR superfamily, member 3) |
Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
Synonyms: | LTBR, D12S370, CD18, LT-BETA-R, Lymphotoxin B receptor, Lymphotoxin-beta receptor, TNFR3, TNF-R-III, TNF-RIII, TNFCR, TNFRSF3, TNFR-III, TNFR-RP, TNFR2-RP |
Target Sequences: | NM_002342 NP_002333.1 P36941 |
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