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ITGB4 / Integrin Beta 4

integrin, beta 4

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Name: integrin, beta 4
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGB4, CD104, Integrin beta-4, Integrin Beta 4, gp150, CD104 antigen, Integrin beta-4 subunit, Integrin, beta 4
Target Sequences: NM_000213 NP_000204.3 P16144

Publications (3)

1
Role of Integrin ß4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress. Chen W, Epshtein Y, Ni X, Dull RO, Cress AE, Garcia JG, Jacobson JR. Scientific reports. 2015 5:16529. (IP; Human) [Full Text Article] [PubMed:26572585] [PMC:PMC4647208] Related Antibodies: LS-C14098.
2
BRCA1 mutation influences progesterone response in human benign mammary organoids. Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E Clare, Seema A Khan, J Julie Kim. Breast cancer research : BCR. 2019 Nov;21:124. [Full Text Article] [PubMed:31771627] [PMC:PMC6878650] Related Antibodies: LS-B3778.
3
A case of oral mucous membrane pemphigoid with IgG antibodies to integrin alpha 6 beta 4. Miyamoto S, Chikazu D, Yasuda T, Enomoto A, Oh-i T, Hirako Y, Tsuchisaka A, Yasukochi A, Sogame R, Teye K, Koga H, Ishii N, Qian H, Li X, Hashimoto T. The British journal of dermatology. 1995 Dec;171:1555-7. [Full Text Article] [PubMed:24836504] Related Antibodies: LS-B9845.

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ELISA Kits (3)
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ITGB4 / Integrin Beta 4 (3)
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96-Well Microplate (2)
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ITGB4 / Integrin Beta 4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ITGB4 / Integrin Beta 4 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ITGB4 / Integrin Beta 4 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).