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IGFBP3
insulin-like growth factor binding protein 3
IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Gene Name: | insulin-like growth factor binding protein 3 |
| Synonyms: | IGFBP3, Binding protein 29, Binding protein 53, BP-53, IGF-binding protein 3, IGFBP-3, IBP-3, IBP3 |
| Target Sequences: | NM_000598 NP_000589.2 P17936 |
Publications (2)
1
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J. Nature communications. 2016 7:13685. (WB; Human)
[Full Text Article]
[PubMed:27897169]
Related Antibodies: LS-C407922.
2
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha Jr, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zu. Nature communications. 2022 February;13:684. [Full Text Article]
[PubMed:35115561]
[PMC:PMC8813914]
Related Antibodies: LS-C340284.
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IGFBP3
(94)
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(86)
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(34)
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Publications
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(92)
Yes
(2)
IGFBP3 Rabbit anti-Human Polyclonal (aa214-252) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Neuroscience
IGFBP3 Rabbit anti-Human Polyclonal (aa130-179) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
IGFBP3 Goat anti-Human Polyclonal (aa191-205) Antibody
Mouse, Goat, Dog, Sheep, Bovine, Rat, Pig, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
IGFBP3 Mouse anti-Human Monoclonal (aa28-297) (OTI3B9) Antibody
Human
WB
Unconjugated
100 µl/$434
IGFBP3 Rabbit anti-Cow Polyclonal (aa106-241) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
IGFBP3 Rabbit anti-Cow Polyclonal (aa106-241) (HRP) Antibody
Bovine, Cow
WB
HRP Conjugated
100 µl/$349; 200 µl/$407; 500 µl/$606; 1 ml/$757; 2 ml/$995; 5 ml/$1,721
IGFBP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
IGFBP3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IGFBP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
IGFBP3 Rabbit anti-Human Polyclonal (aa182-198) Antibody
Goat, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IGFBP3 Rabbit anti-Rat Polyclonal (aa163-193) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
IGFBP3 Rabbit anti-Mouse Polyclonal (aa151-291) Antibody
Mouse
WB
Unconjugated
100 µl/$273; 200 µl/$300; 500 µl/$390; 1 ml/$435; 2 ml/$524; 5 ml/$883
IGFBP3 Rabbit anti-Human Monoclonal (Preservative Free) (010) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
IGFBP3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
IGFBP3 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$575
IGFBP3 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IGFBP3 Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IGFBP3 Rabbit anti-Human Polyclonal (aa163-193) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
IGFBP3 Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IGFBP3 Rabbit anti-Human Polyclonal (p183) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
IGFBP3 Rabbit anti-Human Polyclonal (Ser183) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
IGFBP3 Rabbit anti-Human Polyclonal (Ser183) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
IGFBP3 Rabbit anti-Human Polyclonal (Ser183) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
IGFBP3 Rabbit anti-Human Polyclonal (Ser183) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
IGFBP3 Rabbit anti-Human Polyclonal (Ser183) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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product results
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