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HSPA5 / GRP78 / BiP

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Name: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Synonyms: HSPA5, BIP, Heat shock 70 kDa protein 5, MIF2, GRP-78, GRP78
Target Sequences: M19645 AAA52614.1 P11021

Publications (10)

1
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ. American journal of physiology. Endocrinology and metabolism. 2013 304:E392-404. (WB; Mouse) [PubMed:23233541] [PMC:PMC3566505]
2
Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8 T cell priming. Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M. PloS one. 2012 7:e51845. [PubMed:23272178] [PMC:PMC3525659] Related Antibodies: LS-C165064.
3
Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. Zhu Y, Xu H, Chen H, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C. Molecular & cellular proteomics : MCP. 2014 13:2593-603. (WB; Human, Rat) [Full Text Article] [PubMed:24997997] [PMC:PMC4188989]
4
Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?. Van Hoesen K, Meynier S, Ribaux P, Petignat P, Delie F, Cohen M. Oncotarget. 2017 November;8:107176-107187. (Human) [Full Text Article] [PubMed:29291021] [PMC:PMC5739806] Related Antibodies: LS-C165063.
5
BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway. Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR. BMC cancer. 2018 April;18:412. (Human) [Full Text Article] [PubMed:29649984] [PMC:PMC5898062] Related Antibodies: LS-C312961.
6
Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia. Haimei Qin, Rong Wang, Xiaoxia Pang, Yuxiao Wei, Fenglian Yang, Junli Wang. Journal of assisted reproduction and genetics. 2018 December;35:2223-2231. [Full Text Article] [PubMed:30229503] [PMC:PMC6289912]
7
Auxiliary proteins that facilitate formation of collagen-rich deposits in the posterior knee capsule in a rabbit-based joint contracture model. Andrzej Steplewski, Jolanta Fertala, Pedro K Beredjiklian , Joseph A Abboud , Mark L Y Wang , Surena Namdari , Jonathan Barlow , Michael Rivlin , William V Arnold , James Kostas, Cheryl Hou, Andrzej Fertala. The Breast : official journal of the European Society of Mastology. 2016 Mar;;34:489-501. [Full Text Article] [PubMed:26241613] Related Antibodies: LS-B4157.
8
Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease. Yeawon Kim, Zheyu Wang, Chuang Li, Kendrah Kidd, Yixuan Wang, Bryce G Johnson, Stanislav Kmoch, Jeremiah J Morrissey, Anthony J Bleyer, Jeremy S Duffield, Srikanth Singamaneni, Ying Maggie Chen. American journal of physiology. Renal physiology. 2021 July;321:F236-F244. [Full Text Article] [PubMed:34251273] [PMC:PMC8424663] Related Antibodies: LS-B2038.
9
Endoplasmic reticulum-resident chaperones modulate the inflammatory and angiogenic responses of endothelial cells. R Tsaryk, N M Bartholomä, N Simiantonaki, L Anspach, K Peters, C Heilmann, C J Kirkpatrick, F Pröls. The British journal of dermatology. 2015 August;173:416-27. [Full Text Article] [PubMed:25832777] Related Antibodies: LS-B4157.
10
Quercetin Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis by Inhibiting the Glucose Regulatory Protein 78 Activation. Yeter Topçu-Tarladaçalisir, Melike Sapmaz-Metin, Zeynep Mercan, Deniz Erçetin. Balkan medical journal. 2024 January;41:30-37. [Full Text Article] [PubMed:38173174] [PMC:PMC10767780] Related Antibodies: LS-C312961.
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HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (aa525-628) (4E3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
HSPA5 / GRP78 / BiP Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 / BIP antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Monoclonal (Gly584) Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$565
HSPA5 / GRP78 / BiP Antibody - HSPA5 / GRP78 / BIP antibody. IHC(P): Rat Intestine Tissue.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa603-617) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HSPA5 / GRP78 / BiP Antibody - HSPA5 Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa261-289) Antibody
Zebrafish, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
HSPA5 / GRP78 / BiP Antibody - HSPA5 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa541-568) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
HSPA5 / GRP78 / BiP Antibody - Western blot of COS7 cell lysate using GRP78 Antibody
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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HSPA5 / GRP78 / BiP Mouse anti-Rat Monoclonal (aa649-654) (10C3) Antibody
Rat, Yeast
ELISA, ICC, IHC, IP, WB
Unconjugated
50 µg/$582
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (RPE) (6H4.2G7) Antibody
Human
ELISA, WB
RPE Conjugated
100 µg/$451
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 / BIP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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HSPA5 / GRP78 / BiP Rabbit anti-Rat Polyclonal (aa645-654) Antibody
Xenopus, Fungus, Rat, Hamster, Rabbit, Mouse, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HSPA5 / GRP78 / BiP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
HSPA5 / GRP78 / BiP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
HSPA5 / GRP78 / BiP ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HSPA5 / GRP78 / BiP Protein - Recombinant Heat Shock 70kDa Protein 5 By SDS-PAGE
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E. coli
His, N-Terminal
24.7 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
HSPA5 / GRP78 / BiP ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
HSPA5 / GRP78 / BiP ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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E. coli
His, N-Terminal
10 µg/$262; 50 µg/$339; 200 µg/$642; 1 mg/$1,623; 5 mg/$2,562; 2 mg/$1,796
HSPA5 / GRP78 / BiP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
HSPA5 / GRP78 / BiP Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
HSPA5 / GRP78 / BiP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
HSPA5 / GRP78 / BiP Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
~80-100 kDa
10 µg/$289; 50 µg/$360; 200 µg/$646
HSPA5 / GRP78 / BiP Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Goat anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
HSPA5 / GRP78 / BiP Antibody - Immunohistochemical analysis of paraffin-embedded Colorectal cancer using BiP/GRP78 (C-terminus) mouse monoclonal antibody (1:100 dilution).Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$391
HSPA5 / GRP78 / BiP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Viewing 1-25 of 196 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).