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HSPA5 / GRP78 / BiP

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Name:	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Synonyms:	HSPA5, BIP, Heat shock 70 kDa protein 5, MIF2, GRP-78, GRP78
Target Sequences:	M19645 AAA52614.1 P11021

Publications (10)

NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ. American journal of physiology. Endocrinology and metabolism. 2013 304:E392-404. (WB; Mouse) [PubMed:23233541] [PMC:PMC3566505]

Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8 T cell priming. Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M. PloS one. 2012 7:e51845. [PubMed:23272178] [PMC:PMC3525659] Related Antibodies: LS-C165064.

Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. Zhu Y, Xu H, Chen H, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C. Molecular & cellular proteomics : MCP. 2014 13:2593-603. (WB; Human, Rat) [Full Text Article] [PubMed:24997997] [PMC:PMC4188989]

Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?. Van Hoesen K, Meynier S, Ribaux P, Petignat P, Delie F, Cohen M. Oncotarget. 2017 November;8:107176-107187. (Human) [Full Text Article] [PubMed:29291021] [PMC:PMC5739806] Related Antibodies: LS-C165063.

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway. Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR. BMC cancer. 2018 April;18:412. (Human) [Full Text Article] [PubMed:29649984] [PMC:PMC5898062] Related Antibodies: LS-C312961.

Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia. Haimei Qin, Rong Wang, Xiaoxia Pang, Yuxiao Wei, Fenglian Yang, Junli Wang. Journal of assisted reproduction and genetics. 2018 December;35:2223-2231. [Full Text Article] [PubMed:30229503] [PMC:PMC6289912]

Auxiliary proteins that facilitate formation of collagen-rich deposits in the posterior knee capsule in a rabbit-based joint contracture model. Andrzej Steplewski, Jolanta Fertala, Pedro K Beredjiklian , Joseph A Abboud , Mark L Y Wang , Surena Namdari , Jonathan Barlow , Michael Rivlin , William V Arnold , James Kostas, Cheryl Hou, Andrzej Fertala. The Breast : official journal of the European Society of Mastology. 2016 Mar;;34:489-501. [Full Text Article] [PubMed:26241613] Related Antibodies: LS-B4157.

Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease. Yeawon Kim, Zheyu Wang, Chuang Li, Kendrah Kidd, Yixuan Wang, Bryce G Johnson, Stanislav Kmoch, Jeremiah J Morrissey, Anthony J Bleyer, Jeremy S Duffield, Srikanth Singamaneni, Ying Maggie Chen. American journal of physiology. Renal physiology. 2021 July;321:F236-F244. [Full Text Article] [PubMed:34251273] [PMC:PMC8424663] Related Antibodies: LS-B2038.

Endoplasmic reticulum-resident chaperones modulate the inflammatory and angiogenic responses of endothelial cells. R Tsaryk, N M Bartholomä, N Simiantonaki, L Anspach, K Peters, C Heilmann, C J Kirkpatrick, F Pröls. The British journal of dermatology. 2015 August;173:416-27. [Full Text Article] [PubMed:25832777] Related Antibodies: LS-B4157.

Quercetin Attenuates Endoplasmic Reticulum Stress and Apoptosis in TNBS-Induced Colitis by Inhibiting the Glucose Regulatory Protein 78 Activation. Yeter Topçu-Tarladaçalisir, Melike Sapmaz-Metin, Zeynep Mercan, Deniz Erçetin. Balkan medical journal. 2024 January;41:30-37. [Full Text Article] [PubMed:38173174] [PMC:PMC10767780] Related Antibodies: LS-C312961.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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