HNF4A / HNF4

hepatocyte nuclear factor 4, alpha

Hepatocyte nuclear factor 4 alpha (HNF4 alpha), a NR2 Hepatocyte NF4-Like receptor, is a liver-enriched transcription factor that is involved in the expression of liver-specific genes. HNF4 alpha controls the expression of transcription factor HNF1, which is important in the expression of hepatic genes, including those involved in glucose, cholesterol, and fatty acid metabolism. HNF4 alpha is essential for hepatocyte differentiation during liver development, metabolic regulation, and liver function. Although HNF4 alpha is a tissue-specific transcription factor, it is also an essential regulator of early embryonic events. Mutations in the HNF4 alpha gene are responsible for type-1 maturity-onset diabetes of the young (MODY1), which is characterized by a defect in insulin secretion. Mutations in HNF4 alpha binding sites have been linked to hemophilia B Leyden, atherosclerosis, hepatitis, and other diseases. HNF4 alpha has been linked to liver cancer via hepatitis and hepatitis B viral infections. Mouse embryos lacking HNF4 alpha fail to complete gastrulation due to dysfunction of the visceral endoderm. Recently, it has been shown that HNF4 alpha is critically involved in the PXR- and CAR-mediated transcriptional activation of CYP3A4, a gene involved in the metabolism of a wide range of drugs Tirona et al. 2003. At least four isoforms (HNF4 alpha1/HNF4B, HNF4 alpha2/HNF4A, HNF4 alpha3/HNF4C, and HNF4 alpha4) are produced by alternative splicing.

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ELISA Kits (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (1)

Sandwich (3)

Sandwich CLIA (1)

Target

HNF4A / HNF4 (7)

Reactivity

Human (3)

Mouse (5)

Rat (3)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (4)

96-Well Strip Plate (2)

Publications

No (7)

Sample Type

Adherent Cell Cultures (2)

Plasma (4)

Serum (4)

Tissue Homogenates (1)

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Rat HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F38651

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F23712

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

39.06 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse/Human/Rat HNF4A / HNF4 (Cell-Based ELISA) ELISA Kit - LS-F2054

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F35567

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

39.063 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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Mouse HNF4A / HNF4 (CLIA) ELISA Kit - LS-F30771

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human HNF4A / HNF4 (Custom ELISA) ELISA Kit - LS-F50616

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$823

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Mouse/Human/Rat Phospho-HNF4A / HNF4 (Ser313) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1531

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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