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GZMB / Granzyme B
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
| Gene Name: | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | GZMB, CCPI, CGL-1, Cathepsin G-like 1, CSP-B, CTLA-1, CTLA1, CGL1, CSPB, Fragmentin 2, GRB, HLP, Human lymphocyte protein, Fragmentin-2, SECT, Lymphocyte protease, T-cell serine protease 1-3E, C11, CTSGL1, Cytotoxic serine protease B, Granzyme B, Granzyme-2 |
| Target Sequences: | NM_004131 NP_004122.2 P10144 |
Publications (4)
1
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. The Journal of clinical investigation. 2019 February;129:902-914. [Full Text Article]
[PubMed:30667372]
[PMC:PMC6355225]
Related Antibodies: LS-B7602.
2
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Celestine N Wanjalla, Wyatt J McDonnell, Ramesh Ram, Abha Chopra, Rama Gangula, Shay Leary, Mona Mashayekhi, Joshua D Simmons, Christian M Warren, Samuel Bailin, Curtis L Gabriel, Liang Guo, Briana D Furch, Morgan C Lima, Beverly O Woodward, LaToya Hannah, Mark A Pilkinton, Daniela T Fuller, Kenji Kawai, Renu Virmani, Aloke V Finn, Alyssa H Hasty, Simon A Mallal, Spyros A Kalams, John R Koethe. Cell reports. Medicine. 2021 February;2:100205. [Full Text Article]
[PubMed:33665640]
[PMC:PMC7897802]
Related Antibodies: LS-B7602.
3
Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages. Emeric Limagne, Marion Thibaudin, Lisa Nuttin, Aodrenn Spill, Valentin Derangère, Jean-David Fumet, Nadia Amellal, Elisa Peranzoni, Valérie Cattan, François Ghiringhelli. Cancer immunology research. 2019 December;7:1958-1969. [Full Text Article]
[PubMed:31611243]
Related Antibodies: LS-B2783.
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GZMB / Granzyme B
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(122)
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(3)
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(1)
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(4)
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(7)
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Low endotoxin level
(7)
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Biologically active
(2)
GZMB / Granzyme B Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
GZMB / Granzyme B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
50 µl/$495
GZMB / Granzyme B Mouse anti-Human Monoclonal (aa21-247) (OTI4E6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
GZMB / Granzyme B Mouse anti-Human Monoclonal (GB11) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$385
GZMB / Granzyme B Mouse anti-Human Monoclonal (Biotin) (GB10) Antibody
Human
ELISA
Biotin Conjugated
0.1 mg/$542
GZMB / Granzyme B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
Baculovirus
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
28.9 kDa
2 µg/$268; 10 µg/$349
Sandwich
96-Well Strip Plate
Monkey
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
GZMB / Granzyme B Mouse anti-Human Monoclonal (OTI4E4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
GZMB / Granzyme B Mouse anti-Human Monoclonal (351927) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$896
GZMB / Granzyme B Rabbit anti-Human Polyclonal (aa175-203) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His, N-Terminal
29.4 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
GZMB / Granzyme B Mouse anti-Human Monoclonal (GRB-7) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
250 µl/$860
GZMB / Granzyme B Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
GZMB / Granzyme B Mouse anti-Human Monoclonal (GM4C1) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$771
GZMB / Granzyme B Mouse anti-Human Monoclonal (4F5) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
GZMB / Granzyme B Mouse anti-Human Monoclonal (GB7) Antibody
Human
IHC, IHC-P
Unconjugated
0.1 mg/$385
GZMB / Granzyme B Rabbit anti-Human Polyclonal (aa21-247) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
GZMB / Granzyme B Rabbit anti-Human Monoclonal Antibody
Human
IHC
Unconjugated
3 ml/$303; 100 µl/$335; 6 ml/$375; 200 µl/$427
GZMB / Granzyme B Mouse anti-Human Monoclonal (Biotin) (GB10) Antibody
Human, Monkey
ELISA
Biotin Conjugated
100 µg/$842
GZMB / Granzyme B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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