Target
Human GZMB / Granzyme B
Synonyms
GZMB | CCPI | CGL-1 | Cathepsin G-like 1 | CSP-B | CTLA-1 | CTLA1 | CGL1 | CSPB | Fragmentin 2 | GRB | HLP | Human lymphocyte protein | Fragmentin-2 | SECT | Lymphocyte protease | T-cell serine protease 1-3E | C11 | CTSGL1 | Cytotoxic serine protease B | Granzyme B | Granzyme-2
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Generated by genetic immunization of BALB/c mice with an immunization vector containing the granzyme B cDNA.
Specificity
Recognizes granzyme B transiently expressed on the cell surface of transfected BOSC cells as well as the native protein in peripheral blood mononuclear cells. Reacts with human granzyme B GrB), a 27kD serine protease which cleaves target-cell proteins at specific aspartate residues. Does not cross-react with the human granzymes A, K or M.