FAP Alpha

fibroblast activation protein, alpha

Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

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Antibodies (61)

Proteins (12)

ELISA Kits (11)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (61)

Recombinant (10)

Sandwich (10)

Target

FAP Alpha (84)

Reactivity

Human (58)

Mouse (25)

Rat (8)

Bat (3)

Bovine (1)

Chicken (3)

Chimpanzee (3)

Gibbon (3)

Horse (1)

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IHC (13)

IHC-Fr (1)

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WB (51)

Flo (2)

ELISA (22)

ICC (3)

IF (5)

IP (2)

Peptide-ELISA (2)

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rabbit (56)

mouse (5)

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IHCPlus (3)

Isotype

IgG (30)

IgG1 (2)

IgG2a,k (2)

Clonality

monoclonal mc (4)

polyclonal pc (56)

recombinant monoclonal rmc (1)

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2F2 (1)

9H122 (1)

F11-24 (1)

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aa523-760 (8)

aa542-761 (8)

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aa652-701 (4)

Extracellular Domain (3)

300-380 aa, Internal (1)

Internal (1)

aa26-280 (1)

aa26-760 (1)

aa525-625 (1)

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Yes (1)

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Adherent Cell Cultures (1)

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Cell Lysates (2)

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Serum (10)

Tissue Homogenates (4)

Tag

6His-SUMO, N-terminus (1)

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His (1)

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His, N-terminus + His, C-terminus (1)

His,N-terminus (1)

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Species

Human (8)

Mouse (3)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (3)

Human Cells (1)

Wheat Germ Extract (2)

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Purified (2)

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Biologically active (1)

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IHC-plus™ FAP Alpha Antibody (Extracellular Domain) LS-A8023

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(5.0) Rating

(2) Publication(s)

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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IHC-plus™ FAP Alpha Antibody (Extracellular Domain) LS-A8027

Fast Shipping

(4.0) Rating

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ FAP Alpha Antibody (Extracellular Domain) LS-A8025

Fast Shipping

(4.0) Rating

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Horse, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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FAP Alpha Antibody (Internal) LS-C413071

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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FAP Alpha Antibody LS-C800644

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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FAP Alpha Antibody (clone F11-24) LS-C6818

Antibody:

FAP Alpha Mouse anti-Human Monoclonal (F11-24) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-Fr, IP

Format:

Unconjugated

Price:

100 µg/$751

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FAP Alpha Antibody (aa26-760, clone 9H122) LS-C125605

Antibody:

FAP Alpha Mouse anti-Human Monoclonal (aa26-760) (9H122) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µg/$938

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FAP Alpha Antibody LS-C154234

Antibody:

FAP Alpha Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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FAP Alpha Antibody LS-C417163

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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FAP Alpha Antibody LS-C401664

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Human FAP Alpha (Sandwich ELISA) ELISA Kit - LS-F2824

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

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Rat FAP Alpha (Sandwich ELISA) ELISA Kit - LS-F8638

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Mouse FAP Alpha (Sandwich ELISA) ELISA Kit - LS-F7697

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

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Mouse FAP Alpha (Sandwich ELISA) ELISA Kit - LS-F49804

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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FAP Alpha Antibody (aa542-761) LS-C372987

Antibody:

FAP Alpha Rabbit anti-Mouse Polyclonal (aa542-761) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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Human FAP Alpha Protein (Recombinant His, N-Terminal) (aa523-760) - LS-G14945

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.4 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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FAP Alpha Antibody LS-C166882

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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FAP Alpha Antibody (300-380 aa, Internal) LS-C386028

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (300-380 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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FAP Alpha Antibody (clone 2F2) LS-C139462

Antibody:

FAP Alpha Mouse anti-Human Monoclonal (2F2) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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FAP Alpha Antibody (aa652-701) LS-C201514

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (aa652-701) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Human FAP Alpha Protein (Recombinant GST) (aa26-760) - LS-G20724

Source:

E. coli

Tag:

GST

Molecular Weight:

112.4 kD

Price:

100 µg/$420; 1 mg/$1,355; 20 µg/$323

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Mouse FAP Alpha Protein (Recombinant His-T7) (aa542-761) - LS-G24879

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Mouse FAP Alpha Protein (Recombinant 6His-SUMO, N-terminus) (aa26-761) - LS-G64301

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

100 µg/$1,128; 20 µg/$721

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FAP Alpha Antibody (aa26-280) LS-C377367

Antibody:

FAP Alpha Rabbit anti-Human Polyclonal (aa26-280) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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FAP Alpha Antibody (aa525-625, Azide-free) LS-C183626

Antibody:

FAP Alpha Mouse anti-Human Monoclonal (aa525-625) (Azide-free) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated, Azide-free

Price:

100 µg/$705

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