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DNASE1 / DNase I
deoxyribonuclease I
DNASE1 / DNase I is a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
| Gene Name: | deoxyribonuclease I |
| Synonyms: | DNASE1, Deoxyribonuclease I, Deoxyribonuclease i precursor, DNase I, DNL1, DRNI, Deoxyribonuclease-1, DNase I, lysosomal |
| Target Sequences: | NM_005223 NP_005214.2 P24855 |
Publications (5)
1
TNFα Amplifies DNaseI Expression in Renal Tubular Cells while IL-1β Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form. Thiyagarajan D, Rekvig OP, Seredkina N. PloS one. 2015 10:e0129485. (IHC, WB; Mouse, Human)
[Full Text Article]
[PubMed:26065428]
[PMC:PMC4465975]
Related Antibodies: LS-B4846.
2
IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human)
[Full Text Article]
[PubMed:29468159]
[PMC:PMC5807897]
Related Antibodies: LS-B4846.
3
Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression. Pedersen HL, Horvei KD, Thiyagarajan D, Norby GE, Seredkina N, Moroni G, Eilertsen GØ, Holdaas H, Strøm EH, Bakland G, Meroni PL, Rekvig OP. The journal of pathology Clinical research. 2018 July;4:193-203. [Full Text Article]
[PubMed:29624903]
[PMC:PMC6065113]
Related Antibodies: LS-B4846.
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(52)
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DNASE1 / DNase I
(52)
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(43)
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(44)
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(34)
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(2)
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(25)
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(5)
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(7)
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(21)
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(16)
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(4)
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(51)
Yes
(1)
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
DNASE1 / DNase I Mouse anti-Human Monoclonal (aa19-259) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
DNASE1 / DNase I Rabbit anti-Human Monoclonal (Preservative Free) (006) Antibody
Human
ELISA, ICC, IF
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
DNASE1 / DNase I Rabbit anti-Human Polyclonal (aa19-259) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
DNASE1 / DNase I Rabbit anti-Human Polyclonal (aa19-259) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
DNASE1 / DNase I Goat anti-Bovine Polyclonal Antibody
Bovine
ELISA, WB
Unconjugated
100 µl/$832
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Liquid) (Biotin) Antibody
Bovine
ELISA, IP, WB
Biotin Conjugated, Liquid
25 µl/$304
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Lyophilized) (Biotin) Antibody
Bovine
ELISA, IP, WB
Biotin Conjugated, Lyophilized
100 µg/$552
DNASE1 / DNase I Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$346; 500 µl/$482; 1 ml/$550; 2 ml/$731; 5 ml/$1,200
DNASE1 / DNase I Mouse anti-Human Monoclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$315; 200 µl/$360; 500 µl/$509; 1 ml/$584; 2 ml/$804; 5 ml/$1,305
DNASE1 / DNase I Mouse anti-Human Monoclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$343; 200 µl/$401; 500 µl/$590; 1 ml/$731; 2 ml/$969; 5 ml/$1,663
DNASE1 / DNase I Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal Antibody
Bovine
ELISA, IHC, IP, WB
Unconjugated
2 ml/$1,225
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
DNASE1 / DNase I Rabbit anti-Human Polyclonal (aa87-121) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Lyophilized) (HRP) Antibody
Bovine
ELISA, IP, WB
HRP Conjugated, Lyophilized
100 µg/$552
DNASE1 / DNase I Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
DNASE1 / DNase I Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
DNASE1 / DNase I Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Lyophilized) Antibody
Bovine
ELISA, IP, WB
Unconjugated, Lyophilized
100 µg/$567
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Liquid) Antibody
Bovine
ELISA, IP, WB
Unconjugated, Liquid
25 µl/$304
DNASE1 / DNase I Rabbit anti-Bovine Polyclonal (Liquid) (HRP) Antibody
Bovine
ELISA, IP, WB
HRP Conjugated, Liquid
25 µl/$304
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