CYLD

cylindromatosis (turban tumor syndrome)

Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.

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Products

Antibodies (31)

Proteins (9)

ELISA Kits (2)

Type

Development Kit (1)

Over-Expression Lysate (4)

Primary (31)

Recombinant (5)

Sandwich (1)

Target

CYLD (42)

Reactivity

Human (32)

Mouse (10)

Rat (8)

Bovine (2)

Chicken (1)

Dog (1)

Guinea pig (1)

Hamster (2)

Horse (2)

Monkey (1)

Pig (1)

Rabbit (1)

Sheep (1)

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Application

IHC (5)

IHC-P (3)

WB (25)

Flo (1)

ELISA (6)

ICC (1)

IF (2)

IP (1)

Peptide-ELISA (2)

Host

rabbit (28)

mouse (2)

goat (1)

Product Group

DevKit DuoPlus (1)

IHCPlus (2)

Isotype

IgG (15)

IgG2a,k (2)

Clonality

monoclonal mc (2)

polyclonal pc (29)

Clone

1667CT857.3.6.1 (1)

2C3 (1)

Format

96-Well Strip Plate (1)

Antibody Pair and Standard (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (21)

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Epitope

aa170-338 (8)

N-Terminus (1)

Ser418 (1)

Ser422 (1)

aa32-45 (1)

aa364-378 (1)

aa618-956 (1)

pSer418 (1)

Publications

No (42)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Tissue Homogenates (2)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (7)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (1)

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IHC-plus™ CYLD Antibody (aa364-378) LS-B4323

(4.0) Rating

Antibody:

CYLD Goat anti-Mouse Polyclonal (aa364-378) Antibody

Reactivity:

Mouse, Rat, Hamster

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ CYLD Antibody (clone 1667CT857.3.6.1) LS-B16765

(4.0) Rating

Antibody:

CYLD Mouse anti-Human Monoclonal (1667CT857.3.6.1) Antibody

Reactivity:

Human

Applications:

Flo, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$460

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CYLD Antibody (aa32-45) LS-C19400

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa32-45) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Hamster, Horse, Human, Monkey

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$386

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CYLD Antibody (clone 2C3) LS-C197008

Antibody:

CYLD Mouse anti-Human Monoclonal (2C3) Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

100 µg/$423

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CYLD Antibody (aa618-956) LS-C407756

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa618-956) Antibody

Reactivity:

Sheep, Bovine, Rat, Pig, Horse, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CYLD Antibody LS-C672368

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CYLD Antibody LS-C660220

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Human CYLD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83793

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.9 kDa

Price:

20 µg/$215

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CYLD Antibody LS-C802698

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CYLD Antibody LS-C406335

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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CYLD Antibody LS-C779659

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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CYLD Antibody LS-C413715

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$394

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CYLD Antibody LS-C64150

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$649

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CYLD Antibody (phospho-Ser418) LS-C128465

Antibody:

CYLD Rabbit anti-Human Polyclonal (pSer418) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$689

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CYLD Antibody (Ser422) LS-C777758

Antibody:

CYLD Rabbit anti-Human Polyclonal (Ser422) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

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CYLD Antibody LS-C777890

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

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CYLD Antibody (Ser418) LS-C778259

Antibody:

CYLD Rabbit anti-Human Polyclonal (Ser418) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

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CYLD Antibody LS-C778315

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$357

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CYLD Antibody (N-Terminus) LS-C357824

Antibody:

CYLD Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$364; 100 µg/$511

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CYLD Antibody LS-C490218

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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CYLD Antibody LS-C668377

Antibody:

CYLD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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CYLD Antibody (aa170-338) LS-C314915

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa170-338) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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CYLD Antibody (aa170-338, HRP) LS-C711474

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa170-338) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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CYLD Antibody (aa170-338, Biotin) LS-C687093

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa170-338) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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CYLD Antibody (aa170-338, APC) LS-C717791

Antibody:

CYLD Rabbit anti-Human Polyclonal (aa170-338) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• APC

• Unconjugated
• HRP
• Biotin
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  • APC

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