COMT

catechol-O-methyltransferase

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

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Antibodies (70)

Type

Primary (70)

Target

COMT (70)

Reactivity

Human (52)

Mouse (28)

Rat (16)

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rabbit (64)

mouse (3)

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IHCPlus (8)

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IgG1 (1)

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monoclonal mc (2)

polyclonal pc (68)

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aa111-156 (1)

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IHC-plus™ COMT Antibody (Internal) LS-A8834

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(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (aa52-65) LS-B4880

(4.0) Rating

Antibody:

COMT Goat anti-Human Polyclonal (aa52-65) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ COMT Antibody (aa170-183) LS-B4343

(5.0) Rating

(1) Publication(s)

Antibody:

COMT Goat anti-Human Polyclonal (aa170-183) Antibody

Reactivity:

Bovine, Pig, Horse, Human, Monkey

Applications:

ELISA, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ COMT Antibody (Internal) LS-A8833

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (C-Terminus) LS-A8836

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(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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COMT Antibody (Internal) LS-C352043

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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COMT Antibody LS-C664700

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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COMT Antibody LS-C490215

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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COMT Antibody (aa52-271) LS-C407752

Antibody:

COMT Rabbit anti-Human Polyclonal (aa52-271) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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COMT Antibody LS-C334555

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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IHC-plus™ COMT Antibody (N-Terminus) LS-A8831

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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COMT Antibody LS-C830464

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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IHC-plus™ COMT Antibody (Internal) LS-A9769

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ COMT Antibody (Internal) LS-A9797

Fast Shipping

(4.0) Rating

Antibody:

COMT Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

COMT Antibody (aa94-108) LS-C313303

Antibody:

COMT Rabbit anti-Human Polyclonal (aa94-108) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

COMT Antibody (30-110 aa, Internal) LS-C382850

Antibody:

COMT Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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COMT Antibody LS-C830481

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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COMT Antibody (clone 1G4-1A1) LS-C196950

Antibody:

COMT Mouse anti-Human Monoclonal (1G4-1A1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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COMT Antibody (aa221-271) LS-C290293

Antibody:

COMT Rabbit anti-Human Polyclonal (aa221-271) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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COMT Antibody LS-C804918

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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COMT Antibody LS-C341963

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$346; 100 µl/$443

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COMT Antibody (aa111-156) LS-C313720

Antibody:

COMT Rabbit anti-Human Polyclonal (aa111-156) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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COMT Antibody LS-C756401

Antibody:

COMT Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

COMT Antibody LS-C782205

Antibody:

COMT Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

COMT Antibody LS-C823942

Antibody:

COMT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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