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CD71 / Transferrin Receptor

Transferrin Receptor

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Gene Name: Transferrin Receptor
Family/Subfamily: Protease , Metallopeptidase M28B
Synonyms: TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1
Target Sequences: NM_003234 NP_003225.2 P02786

Publications (2)

1
LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular vesicles. Jackson O Gardner, Andrew M Leidal, Tan A Nguyen, Jayanta Debnath. Autophagy. 2023 May;19:1551-1561. [Full Text Article] [PubMed:36286616] [PMC:PMC10240981] Related Antibodies: LS-C171694.
2
HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. Kim J, Yoon JH, Kim YS. PloS one. 2013 8:e77972. [Full Text Article] [PubMed:24312169] [PMC:PMC3843664] Related Antibodies: LS-B6156.

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Antibodies (286)
Primary (286)
CD71 / Transferrin Receptor (286)
Human (192)
Mouse (73)
Rat (21)
Bovine (1)
Chicken (12)
Chimpanzee (3)
Cynomolgus (2)
Dog (2)
Hamster (4)
Horse (9)
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Rabbit (1)
IHC (56)
IHC-Fr (16)
IHC-P (26)
WB (161)
Flo (127)
ELISA (59)
ICC (43)
IF (32)
IP (58)
Peptide-ELISA (6)
rabbit (113)
mouse (129)
goat (1)
mouse-balb/c (1)
rat (42)
Product Group
IHCPlus (3)
PathPlus Cancer (2)
PathPlus Cancer Pathology (2)
IgG (45)
IgG1 (53)
IgG1,k (16)
IgG2a (33)
IgG2a,k (21)
IgG2b (10)
IgG2b,k (7)
monoclonal mc (173)
polyclonal pc (113)
02 (1)
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04 (2)
040 (1)
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R17 217.1.3/TIB-219 (21)
R17217.1.4 (4)
RI7217 (5)
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TFRC/1059 (2)
TFRC/1149 (2)
TFRC/1396 (2)
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TFRC/1818 (2)
TFRC/1839 (2)
WK7 (2)
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aa567-744 (16)
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aa563-764 (8)
aa572-757 (8)
aa585-771 (8)
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aa107-156 (4)
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10-90 aa (2)
pSer24 (2)
91-140 aa, N-terminal (1)
Tyr20 (1)
aa 94-754 (1)
aa1-198 (1)
aa125-175 (1)
aa14-63 (1)
aa15-64 (1)
aa21-35 (1)
aa3-28 (1)
aa608-727 (1)
p24 (1)
pTyr20 (1)
No (284)
Yes (2)
CD71 / Transferrin Receptor Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (1E6) Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$485
CD71 / Transferrin Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (aa3-28) (H68.4) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, ICC, IF, IHC-P, IP, WB
Unconjugated
50 µg/$485
CD71 / Transferrin Receptor Antibody - Anti-Transferrin Receptor antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CD71 / Transferrin Receptor Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
CD71 / Transferrin Receptor Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CD71 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (aa649-677) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (N-Terminus) (3G291) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
250 µg/$890; 500 µg/$1,453
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CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (Low Endotoxin) (OX-26) Antibody
Rat
Flo, IF, IHC-Fr, IHC-P, WB
Unconjugated, Low Endotoxin
0.5 mg/$712
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CD71 / Transferrin Receptor Rat anti-Mouse Monoclonal (Low Endotoxin) (8D3) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated, Low Endotoxin
0.5 mg/$671
CD71 / Transferrin Receptor Antibody - Immunochemical staining of mouse TFRC in mouse small intestine with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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CD71 / Transferrin Receptor Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
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CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (OX-26) Antibody
Rat
Flo, IHC, IHC-Fr, IP
Unconjugated
250 µg/$359
CD71 / Transferrin Receptor Antibody - TFRC antibody (1 ug/ml) staining of Human Breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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CD71 / Transferrin Receptor Goat anti-Human Polyclonal (aa21-35) Antibody
Rabbit, Dog, Bovine, Hamster, Pig, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (Low Endotoxin) (DF1513) Antibody
Human
Flo, IF
Unconjugated, Low Endotoxin
0.5 mg/$671
CD71 / Transferrin Receptor Antibody - Immunohistochemistry of paraffin-embedded human lung cancer tissue.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CD71 / Transferrin Receptor Antibody - IHC of CD71 on FFPE Bone Marrow tissue.
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (10F11) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$309
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CD71 / Transferrin Receptor Rabbit anti-Cynomolgus Polyclonal Antibody
Cynomolgus
ELISA
Unconjugated
100 µl/$412
CD71 / Transferrin Receptor Antibody - Western blot using TFRC monoclonal antibody against human TFRC recombinant protein. (Expected MW is 39.7 kDa)
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (aa608-727) (1A1B2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$459
CD71 / Transferrin Receptor Antibody - Surface staining of CD71 in K562 cells with anti-CD71 (MEM-189) purified, GAM-APC.
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (MEM-189) Antibody
Human
Flo, IP, WB
Unconjugated
0.1 mg/$302
CD71 / Transferrin Receptor Antibody - Surface staining of NALM-6 human peripheral blood pre-B cell leukemia cell line with anti-CD71 (MEM-75) biotin; detection by Streptavidin-PE .  Total viable cells were used for analysis.
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CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (Biotin) (MEM-75) Antibody
Human
Flo, ICC, IP
Biotin Conjugated
0.1 mg/$337
CD71 / Transferrin Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CD71/TfR Antibody. The picture on the right is blocked with the synthesized peptide.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (aa15-64) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (SOM4D10) Antibody
Human
IHC, IHC-Fr
Unconjugated
200 µg/$523
Select
CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (FITC) (MRC OX-26) Antibody
Rat
Flo
FITC Conjugated
100 µg/$355; 500 µg/$649
Select
CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (FITC) (OX-26) Antibody
Rat
Flo
FITC Conjugated
0.1 mg/$444
CD71 / Transferrin Receptor Antibody - Western Blot; Sample: Recombinant TFR, Human.
Select
CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$327; 200 µl/$377; 1 ml/$642
CD71 / Transferrin Receptor Antibody - Western blot of recombinant CD71 / Transferrin Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD71 / Transferrin Receptor Rabbit anti-Rat Polyclonal (aa587-756) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
Select
CD71 / Transferrin Receptor Rat anti-Mouse Monoclonal (YTA74.4) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
0.25 mg/$471
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).