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CCL2 / MCP1

chemokine (C-C motif) ligand 2

CCL2 / MCP1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Gene Name:	chemokine (C-C motif) ligand 2
Family/Subfamily:	Intercrine , Intercrine beta
Synonyms:	CCL2, C-C motif chemokine 2, Chemokine (C-C motif) ligand 2, GDCF-2, HC11, HSMCR30, MCP1, SCYA2, Small-inducible cytokine A2, Monocyte secretory protein JE, MCAF, MCP-1, Monocyte chemotactic protein 1, SMC-CF
Target Sequences:	NM_002982 NP_002973.1 P13500

Publications (12)

Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis. Zenebech Wondimu, Tania Santodomingo-Garzon, Tai Le, and Mark G. Swain. The American journal of pathology. 2010 177:2334-46. (IHC-P; Mouse) [Full Text Article] [PubMed:20847291] [PMC:PMC2966792]

Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, Fiebeler A, Klinge U, Park JK, Barth S, Thepen T, Tolba RH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:3149-55. (IHC; Rat) [PubMed:22402584]

Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 release and macrophage transepithelial migration. Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection and immunity. 2012 80:3225-35. (Human) [PubMed:22778093] [PMC:PMC3418758]

Small heat shock proteins induce a cerebral inflammatory reaction. Bruinsma IB, de Jager M, Carrano A, Versleijen AA, Veerhuis R, Boelens W, Rozemuller AJ, de Waal RM, Verbeek MM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11992-2000. (ICC; Human) [Full Text Article] [PubMed:21849559] Related Antibodies: LS-C8642.

Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. El-Gazzar AM, Abdelgied M, Alexander DB, Alexander WT, Numano T, Iigo M, Naiki A, Takahashi S, Takase H, Hirose A, Kannno J, Elokle OS, Nazem AM, Tsuda H. Archives of toxicology. 2019 January;93:49-59. [Full Text Article] [PubMed:30341734] [PMC:PMC6343020]

Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention. Nandita Raikwar, Cameron Braverman, Peter M Snyder, Robert A Fenton, David K Meyerholz, Francois M Abboud, Sailesh C Harwani. American journal of physiology. Heart and circulatory physiology. 2019 September;317:H517-H530. [Full Text Article] [PubMed:31172810] [PMC:PMC6766722] Related Antibodies: LS-C104751.

Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. Akiko Nakayama, Julián Albarrán-Juárez, Guozheng Liang, Kenneth Anthony Roquid, András Iring, Sarah Tonack, Min Chen, Oliver J Müller, Lee S Weinstein, Stefan Offermanns. JCI insight. 2020 December;5: [Full Text Article] [PubMed:33268595] [PMC:PMC7714404] Related Antibodies: LS-C169178.

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. Divya Bhatia, Kuei-Pin Chung, Kiichi Nakahira, Edwin Patino, Michelle C Rice, Lisa K Torres, Thangamani Muthukumar, Augustine Mk Choi, Oleh M Akchurin, Mary E Choi. JCI insight. 2019 December;4: [Full Text Article] [PubMed:31639106] [PMC:PMC6962025]

High-fat diet increases the level of circulating Monocyte Chemoattractant Protein-1 in Wistar rats, independent of obesity. Syarif, Haerani Rasyid, Makbul Aman, Gatot S Lawrence. Annals of medicine and surgery (2012). 2021 Apr;65:102266. [Full Text Article] [PubMed:33868686] [PMC:PMC8047162]

Sex Difference in Peripheral Inflammatory Biomarkers in Drug-Naïve Patients with Major Depression in Young Adulthood. Jinho Kim, Jong-Hoon Kim , Keun-A Chang. Biomedicines. 2021 Jun;9:708. [Full Text Article] [PubMed:34206551] [PMC:PMC8301344]

Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver. Nazmul Huda, Bilon Khambu, Gang Liu, Hirokazu Nakatsumi, Shengmin Yan, Xiaoyun Chen, Michelle Ma, Zheng Dong, Keiichi I Nakayama, Xiao-Ming Yin. Cellular and molecular gastroenterology and hepatology. 2022 April;14:333-355. [Full Text Article] [PubMed:35398596] [PMC:PMC9233281]

Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice. Stine Gunnersen, Jeong Tangkjær Shim, Fan Liu, Uwe J F Tietge, Charlotte Brandt Sørensen, Jacob Fog Bentzon. Atherosclerosis plus. 2024 March;55:12-20. [Full Text Article] [PubMed:38234375] [PMC:PMC10874436] Related Antibodies: LS-B10540.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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